Study of Serum Metabonomics and Formula-Pattern Correspondence in Coronary Heart Disease Patients Diagnosed as Phlegm or Blood Stasis Pattern Based on Ultra Performance Liquid Chromatography Mass Spectrometry

Objectives To study the characteristics of serum metabonomics in coronary heart disease (CHD) patients diagnosed as phlegm or blood stasis pattern and explore effects of formula-pattern correspondence treatment. Methods A total of 102 stable CHD patients were enrolled and divided into phlegm group (...

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Bibliographic Details
Published in:Chinese journal of integrative medicine 2018-12, Vol.24 (12), p.905-911
Main Authors: Lu, Xiao-yan, Xu, Hao, Zhao, Tie, Li, Geng
Format: Article
Language:English
Subjects:
Case-Control Studies
Chromatography, High Pressure Liquid
Coronary Disease - blood
Coronary Disease - diagnosis
Discriminant Analysis
Female
Humans
Least-Squares Analysis
Male
Mass Spectrometry - methods
Medicine
Medicine & Public Health
Medicine, Chinese Traditional
Metabolome
Metabolomics
Middle Aged
Original Article
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Summary:Objectives To study the characteristics of serum metabonomics in coronary heart disease (CHD) patients diagnosed as phlegm or blood stasis pattern and explore effects of formula-pattern correspondence treatment. Methods A total of 102 stable CHD patients were enrolled and divided into phlegm group (P group, n =52) and blood stasis group (BS group, n =50) according to pattern identifification. Gualou Xiebai Banxia Decoction (瓜蒌薤白半夏汤, GXBD) and Xuefu Zhuyu Decoction (血府逐瘀汤, XZD) were used as drug interventions. Relevant indicators of metabonomics were observed by ultra performance liquid chromatography mass spectrometry (UPLC-MS) and pattern recognition. Results Levels of amino acids and phosphatidylethanolamine (PE) in the CHD group were much higher than those in healthy control group, while the levels of unsaturated fatty acids, sphingosine, Lyso, phosphatidylcholine (PC) were signifificantly lower ( P
ISSN:1672-0415
1993-0402
DOI:10.1007/s11655-018-2564-7