Acyl-carnitine, C5DC, and C26 as potential biomarkers for diagnosis of autism spectrum disorder in children

•Blood levels of free carnitine, glutaricyl carnitine, octyl carnitine, twenty four carbonyl carnitine and carnosyl carnitine were significantly lower in Chinese preschool children with autism spectrum disorder (ASD).•Our manuscript is the first description about the changes in the acyl-carnitine sp...

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Bibliographic Details
Published in:Psychiatry research 2018-09, Vol.267, p.277-280
Main Authors: Lv, Qian-Qian, You, Cong, Zou, Xiao-Bing, Deng, Hong-Zhu
Format: Article
Language:English
Subjects:
Acyl-carnitine profiles
Autism spectrum disorder (ASD)
Autism Spectrum Disorder - blood
Autism Spectrum Disorder - diagnosis
Autism Spectrum Disorder - epidemiology
Biomarkers - blood
Carnitine - analogs & derivatives
Carnitine - blood
Child
Child, Preschool
Children
China - epidemiology
Female
Humans
Intelligence - physiology
Male
Neurodevelopmental Disorders - blood
Neurodevelopmental Disorders - diagnosis
Neurodevelopmental Disorders - epidemiology
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Summary:•Blood levels of free carnitine, glutaricyl carnitine, octyl carnitine, twenty four carbonyl carnitine and carnosyl carnitine were significantly lower in Chinese preschool children with autism spectrum disorder (ASD).•Our manuscript is the first description about the changes in the acyl-carnitine spectrum in Chinese preschool children with ASD, which indicates potential mitochondrial dysfunction and abnormal fatty acid metabolism in ASD.•Importantly, our findings indicate that blood levels of glutaryl carnitine and carnosyl carnitine might be potential biomarkers for diagnosis of ASD. Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders that shown a close association with impaired lipid metabolism. The acyl-carnitine spectrum status in Chinese children with ASD has not been reported. In this study, we assessed the levels of blood acyl-carnitines in Chinese children with ASD and examined the relation between acyl-carnitine profiles and the intelligence levels. Blood levels of acyl-carnitines were determined by tandem mass spectrometry in 60 children with ASD and 30 typically developing children. Chinese Wechsler Young Children Scale of Intelligence (C-WYCSI) was used in ASD group. Blood levels of free carnitine, glutaricyl carnitine, octyl carnitine, twenty four carbonyl carnitine and carnosyl carnitine in the ASD group were significantly lower than those in the control group. Glutaryl carnitine and carnosyl carnitine might be potential biomarkers for diagnosis of ASD. The changes in the acyl-carnitine spectrum indicate potential mitochondrial dysfunction and abnormal fatty acid metabolism in preschool ASD children.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2018.06.027