Improvements in clinical characteristics of patients with non-alcoholic fatty liver disease, after an intervention based on the Mediterranean lifestyle: a randomised controlled clinical trial

Lifestyle interventions remain the cornerstone therapy for non-alcoholic fatty liver disease (NAFLD). This randomised controlled single-blind clinical trial investigated the effect of Mediterranean diet (MD) or Mediterranean lifestyle, along with weight loss, in NAFLD patients. In all, sixty-three o...

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Bibliographic Details
Published in:British journal of nutrition 2018-07, Vol.120 (2), p.164-175
Main Authors: Katsagoni, Christina N, Papatheodoridis, George V, Ioannidou, Panagiota, Deutsch, Melanie, Alexopoulou, Alexandra, Papadopoulos, Nikolaos, Papageorgiou, Maria-Vasiliki, Fragopoulou, Elizabeth, Kontogianni, Meropi D
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Alcohol use
Body mass
Body weight
Body weight loss
Clinical trials
Diabetes
Diet
Disease control
Enzymes
Evidence-based medicine
Exercise
Fatty liver
Hepatitis
Histology
Insulin resistance
Intervention
Laboratories
Lifestyles
Liver
Liver diseases
Metabolic syndrome
Mortality
Motivation
Overweight
Patients
Physical activity
Physical fitness
Randomization
Sleep
Stiffness
Ultrasonic imaging
Ultrasound
Weight loss
Weight reduction
γ-Glutamyltransferase
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Summary:Lifestyle interventions remain the cornerstone therapy for non-alcoholic fatty liver disease (NAFLD). This randomised controlled single-blind clinical trial investigated the effect of Mediterranean diet (MD) or Mediterranean lifestyle, along with weight loss, in NAFLD patients. In all, sixty-three overweight/obese patients (50 (sd 11) years, BMI=31·8 (sd 4·5) kg/m2, 68 % men) with ultrasonography-proven NAFLD (and elevated alanine aminotransferase (ALT) and/or γ-glutamyl transpeptidase (GGT) levels) were randomised to the following groups: (A) control group (CG), (B) Mediterranean diet group (MDG) or (C) Mediterranean lifestyle group (MLG). Participants of MDG and MLG attended seven 60-min group sessions for 6 months, aiming at weight loss and increasing adherence to MD. In the MLG, additional guidance for increasing physical activity and improving sleep habits were given. Patients in CG received only written information for a healthy lifestyle. At the end of 6 months, 88·8 % of participants completed the study. On the basis of intention-to-treat analysis, both MDG and MLG showed greater weight reduction and higher adherence to MD compared with the CG (all P
ISSN:0007-1145
1475-2662
DOI:10.1017/S000711451800137X