IgG4-related disease: association between chronic rhino-sinusitis and systemic symptoms

Purpose The objective of this study is to analyze the relationship between chronic rhino-sinusitis (CRS) and systemic symptoms in patients with IgG4-related disease (IgG4-RD). Patients and methods The patients with IgG4-RD, confirmed by restrict association with clinical and histopathological manife...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2018-08, Vol.275 (8), p.2013-2019
Main Authors: Gao, Yuan, Zheng, Ming, Cui, Li, Chen, Nan, Wang, Yan-ni, Zhan, Yu-tao, Wang, Zhen-gang
Format: Article
Language:English
Subjects:
Head and Neck Surgery
Medicine
Medicine & Public Health
Neurosurgery
Otorhinolaryngology
Rhinology
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Summary:Purpose The objective of this study is to analyze the relationship between chronic rhino-sinusitis (CRS) and systemic symptoms in patients with IgG4-related disease (IgG4-RD). Patients and methods The patients with IgG4-RD, confirmed by restrict association with clinical and histopathological manifestations between March 2013 and July 2016, were enrolled and followed-up for 1 year at the Tongren Hospital, Capital Medical University. The patients were divided into two groups: the case group included IgG4-RD patients with CRS confirmed by clinical and imaging, while the control group included IgG4-RD patients without CRS confirmed by clinical and imaging. Age, gender, clinical manifestations, the percentage of eosinophils in peripheral blood, sedimentation (ESR), C-reaction protein, serum IgE and IgG4 levels, histopathology, and treatment drugs at the baseline and 1 year of follow-up were compared between the two groups. Results A total of 46 cases met the diagnostic criteria for IgG4-RD. A total of 30 patients (65.2%) had IgG4-RD complicated with CRS, and were aged 49.7 ± 13.4 years, with male:female ratio = 2:1. The disease duration in the case group was longer than that in the control group (3.0 versus 0.8, p  = 0.009). The ratio of ocular involvement was higher (86.7 versus 60%, p  
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-018-5013-5