Daily Consumption of Synbiotic Yogurt Decreases Liver Steatosis in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in developed and developing countries. The use of synbiotics has been proposed as a probable management strategy for patients with NAFLD. We investigated the effects of synbiotic yogurt on hepatic steatosis and liver e...

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Bibliographic Details
Published in:The Journal of nutrition 2018-08, Vol.148 (8), p.1276-1284
Main Authors: Bakhshimoghaddam, Farnush, Shateri, Kamran, Sina, Morad, Hashemian, Maryam, Alizadeh, Mohammad
Format: Article
Language:English
Subjects:
Adult
Alanine
Alanine transaminase
Alkaline phosphatase
Analysis of Variance
Aspartate aminotransferase
Bifidobacterium - growth & development
Body mass
Body mass index
Body size
Clinical trials
Developing countries
Diet
Disease control
Double-Blind Method
Enzymes
Evidence-based medicine
Fatty liver
Feeding Behavior
Female
Humans
Intervention
intestinal microbiota
Inulin
Inulin - analysis
LDCs
Liver
Liver - enzymology
Liver diseases
Logistic Models
Male
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - prevention & control
nonalcoholic fatty liver disease
Oxidative stress
Patients
prebiotic
Prebiotics
probiotic
Probiotics
Randomization
Steatosis
Stress concentration
synbiotic
Synbiotics
Ultrasound
Variance analysis
Yogurt
Yogurt - microbiology
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Summary:Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in developed and developing countries. The use of synbiotics has been proposed as a probable management strategy for patients with NAFLD. We investigated the effects of synbiotic yogurt on hepatic steatosis and liver enzymes as primary outcomes and on oxidative stress markers, adipokine concentration, and gut peptide concentration as secondary outcomes in patients with NAFLD. In this 24-wk, open-label, randomized controlled clinical trial, 102 patients [50 men and 52 women; mean age: 40 y; body mass index (in kg/m2) (mean ± SD): 31.2 ± 4.9] were randomly assigned to 3 groups, including 2 intervention groups and 1 control group. The intervention groups consumed 300 g synbiotic yogurt containing 108 colony-forming units Bifidobacterium animalis/mL and 1.5 g inulin or conventional yogurt daily and were advised to follow a healthy lifestyle (i.e., diet and exercise). The control group was advised to follow a healthy lifestyle alone. We evaluated differences between groups in liver function measures by using repeated-measures ANOVA, ANCOVA, and logistic regression. At the end of the study, the grades of NAFLD, as determined by ultrasonography, showed a significant decrease in the synbiotic group compared with the conventional and control groups (P 
ISSN:0022-3166
1541-6100
DOI:10.1093/jn/nxy088