MRI and luminescence detection of Zn2+ with a lanthanide complex–zinc finger peptide conjugate

A bioinspired probe based on a zinc finger peptide functionalized by a lanthanide(iii)-DOTA monoamide complex turns out to be active for both luminescence and MRI detection of Zn2+, depending on the lanthanide cation. A mechanism for MRI-based detection is proposed.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-07, Vol.54 (53), p.7350-7353
Main Authors: Isaac, Manon, Pallier, Agnès, Szeremeta, Frédéric, Pierre-Alain Bayle, Barantin, Laurent, Bonnet, Célia S, Sénèque, Olivier
Format: Article
Language:English
Subjects:
Luminescence
Zinc
Online Access:Get full text
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Description
Summary:A bioinspired probe based on a zinc finger peptide functionalized by a lanthanide(iii)-DOTA monoamide complex turns out to be active for both luminescence and MRI detection of Zn2+, depending on the lanthanide cation. A mechanism for MRI-based detection is proposed.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc04366c