Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders

Cannabidiol (CBD) is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, antiinflammatory and neuroprotective properties. However, it is well established that CBD produces its bi...

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Bibliographic Details
Published in:Phytotherapy research 2009-05, Vol.23 (5), p.597-602
Main Authors: Scuderi, Caterina, Filippis, Daniele De, Iuvone, Teresa, Blasio, Angelo, Steardo, Antonio, Esposito, Giuseppe
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
cannabidiol
Cannabidiol - pharmacology
Cannabidiol - therapeutic use
Cannabidiol - toxicity
Cannabis - chemistry
Cannabis sativa
Central Nervous System Diseases - drug therapy
CNS disorder
General pharmacology
Humans
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytocannabinoid
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Summary:Cannabidiol (CBD) is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, antiinflammatory and neuroprotective properties. However, it is well established that CBD produces its biological effects without exerting significant intrinsic activity upon cannabinoid receptors. For this reason, CBD lacks the unwanted psychotropic effects characteristic of marijuana derivatives, so representing one of the bioactive constituents of Cannabis sativa with the highest potential for therapeutic use.The present review reports the pharmacological profile of CBD and summarizes results from preclinical and clinical studies utilizing CBD, alone or in combination with other phytocannabinoids, for the treatment of a number of CNS disorders. Copyright © 2008 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.2625