Characterization of monocytic and granulocytic subsets of myeloid‐derived suppressor cells in blood donors with occult hepatitis B virus infection

Myeloid‐derived suppressor cells (MDSCs) accumulate from many diseases. MDSCs are rarely explored in occult hepatitis B virus infection (OBI). The frequency of monocytic MDSCs (M‐MDSCs) and granulocytic MDSCs (G‐MDSCs) in OBI carriers was analyzed for correlation with clinical parameters, which was...

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Bibliographic Details
Published in:Journal of medical virology 2019-02, Vol.91 (2), p.330-335
Main Authors: Zhang, Weiyun, Huang, Jieting, Wang, Min, Song, Dandan, Liao, Qiao, Rong, Xia, Li, Tingting, Allain, Jean‐Pierre, Ren, Guangli, Fu, Yongshui, Li, Chengyao
Format: Article
Language:English
Subjects:
Adult
Blood donors
correlation
Correlation analysis
Female
frequency
Granulocytes - immunology
Hepatitis
Hepatitis B
Hepatitis B surface antigen
Hepatitis B Surface Antigens - blood
Hepatitis B virus - immunology
Hepatitis B, Chronic - pathology
Humans
Infections
Interferon
Male
Middle Aged
Monocytes
Myeloid-Derived Suppressor Cells - immunology
myeloid‐derived suppressor cells
occult hepatitis B virus infection
Parameters
Suppressor cells
T-Lymphocytes - immunology
Viral Load
Virology
Viruses
Young Adult
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Summary:Myeloid‐derived suppressor cells (MDSCs) accumulate from many diseases. MDSCs are rarely explored in occult hepatitis B virus infection (OBI). The frequency of monocytic MDSCs (M‐MDSCs) and granulocytic MDSCs (G‐MDSCs) in OBI carriers was analyzed for correlation with clinical parameters, which was no different between OBI and healthy individuals, whereas the frequency of M‐MDSCs but G‐MDSCs in OBI was significantly lower than that observed in chronic hepatitis B carriers (0.4% vs 0.7%, P = 0.0004). The frequency of MDSCs was not correlated with clinical parameters and viral load of OBI, suggesting that the absence of HBsAg in OBI carriers might not induce the accumulation of MDSCs.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.25242