Effect of long-term nitrite administration on browning of white adipose tissue in type 2 diabetic rats: A stereological study

Nitric oxide (NO) deficiency is associated with obesity and type 2 diabetes. Nitrite, a NO donor, is considered as a new therapeutic agent in diabetes. This study aims at determining effects of long-term nitrite administration on browning of white adipose tissue (WAT) in type 2 diabetic rats. Male r...

Full description

Saved in:
Bibliographic Details
Published in:Life sciences (1973) 2018-08, Vol.207, p.219-226
Main Authors: Varzandi, Tarlan, Abdollahifar, Mahammad Amin, Haeri Rohani, Seyed Ali, Piryaei, Abbas, Zadeh-Vakili, Azita, Jeddi, Sajad, Ghasemi, Asghar
Format: Article
Language:English
Subjects:
Adipose tissue
Body weight
Body weight gain
Brown adipose tissue
Browning
Chemical compounds
Diabetes
Drinking water
Effectiveness
Glucose
Levels
Metabolites
Nitrates
Nitric oxide
Nitrite
Nitrogen oxides
Pharmacology
Rodents
Sodium nitrite
Stereoscopy
Tissues
Type 2 diabetes
White adipose tissue
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nitric oxide (NO) deficiency is associated with obesity and type 2 diabetes. Nitrite, a NO donor, is considered as a new therapeutic agent in diabetes. This study aims at determining effects of long-term nitrite administration on browning of white adipose tissue (WAT) in type 2 diabetic rats. Male rats were divided into 4 groups: Control, control + nitrite, diabetes, and diabetes + nitrite. Sodium nitrite (50 mg/L in drinking water) was administered for 3 months. Body weight was measured weekly. Fasting serum levels of glucose and nitric oxide metabolites (NOx) were measured monthly. Histological evaluations and measurement of cyclic guanosine monophosphate (cGMP) and NOx levels in adipose tissue were done at the end of the study. Nitrite decreased serum glucose concentration and body weight gain in diabetic rats by 27.6% and 37.9%, respectively. In diabetic rats, nitrite increased NOx and cGMP levels in inguinal WAT by 95.7% and 33.1%, respectively. Numerical density in WAT of nitrite-treated diabetic rats was higher than in diabetic ones (995 ± 83 vs. 2513 ± 256 cell/mm3, P 
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2018.06.012