Mechanisms of testosterone deficiency-related endothelial dysfunction: Invited commentary for the Hellenic Journal of Cardiology on: Tsikas et al. “Associations between asymmetric dimethylarginine, nitrite-dependent renal carbonic anhydrase activity and plasma testosterone levels in hypogonadal men”

Mechanisms of testosterone deficiency-related endothelial dysfunction: Invited commentary for the Hellenic Journal of Cardiology on: Tsikas et al. “Associations between asymmetric dimethylarginine, nitrite-dependent renal carbonic anhydrase activity and plasma testosterone levels in hypogonadal men”

Evidence from clinical studies suggests that patients with low testosterone levels are at increased cardiovascular disease risk. Even though the exact mechanisms remain poorly understood, a low plasma testosterone level is associated with a pro-atherogenic lipid profile, insulin resistance and incre...

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Bibliographic Details
Published in:Hellenic journal of cardiology 2018-07, Vol.59 (4), p.207-208
Main Authors: Antonopoulos, Alexios S., Antoniades, Charalambos
Format: Article
Language:eng
Subjects:
Arginine - analogs & derivatives
Asymmetric dimethylarginine
Carbonic Anhydrases
Endothelial dysfunction
Humans
Hypogonadism
Male
Nitric oxide
Nitrites
Testosterone
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Summary:Evidence from clinical studies suggests that patients with low testosterone levels are at increased cardiovascular disease risk. Even though the exact mechanisms remain poorly understood, a low plasma testosterone level is associated with a pro-atherogenic lipid profile, insulin resistance and increased levels of pro-inflammatory mediators and vascular dysfunction, which is typically observed in patients with hypogonadism. Furthermore, recent evidence suggests that testosterone deficiency has also direct adverse effects on the endothelium and nitric oxide (NO) bioavailability. Observations from studies in patients with hypogonadal hypogonadism imply that the mechanisms of endothelial dysfunction related to testosterone deficiency may involve changes in asymmetric dimethylarginine (ADMA) levels, a known endogenous inhibitor of NO synthase. Evidence suggests that testosterone replacement therapy is not only a safe but also an effective means to reduce atherosclerotic risk and reverse endothelial dysfunction in patients with hypogonadal hypogonadism. Further research in the field is expected to clarify whether changes in ADMA metabolism constitute the central mechanism through which a low testosterone level leads to endothelial dysfunction.
ISSN:1109-9666
2241-5955