Silica nano-channel induced i-motif formation and stabilization at neutral and alkaline pH

Here, we have developed a new strategy to stabilize i-motif DNA in neutral and alkaline media by incorporating C-rich sequences inside silica nano-channels. Subsequently, the reversibility of this conformational transition has been achieved using a positively charged protein. Importantly, this entir...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (51), p.7054-7057
Main Authors: Satpathi, Sagar, Das, Konoya, Hazra, Partha
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
DNA
Gene sequencing
Proteins
Silicon dioxide
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Summary:Here, we have developed a new strategy to stabilize i-motif DNA in neutral and alkaline media by incorporating C-rich sequences inside silica nano-channels. Subsequently, the reversibility of this conformational transition has been achieved using a positively charged protein. Importantly, this entire conformational transition can be performed in multiple cycles, which offers an alternative way to control i-motif formation other than pH and thermal annealing.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc02811g