The Effects of Lipid Emulsion, Magnesium Sulphate and Metoprolol in Amitriptyline-Induced Cardiovascular Toxicity in Rats

The aim of this study was to evaluate the effects of metoprolol, lipid emulsion and MgSO 4 which can be recommended for prevention of long QT that is one of the lethal consequences of amitriptyline intoxication. Thirty Sprague–Dawley male rats were included. Five groups respectively received the fol...

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Bibliographic Details
Published in:Cardiovascular toxicology 2018-12, Vol.18 (6), p.547-556
Main Authors: Bora, Saylav, Erdoğan, Mümin Alper, Yiğittürk, Gürkan, Erbaş, Oytun, Parlak, İsmet
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Amitriptyline
Amitriptyline - toxicity
Animals
Anti-Arrhythmia Agents - pharmacology
Antidepressive Agents, Tricyclic - toxicity
Biochemical analysis
Biochemistry
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Calcium-binding protein
Cardiology
Cardiotoxicity
Caspase
Caspase 3 - metabolism
Caspase-3
Electrocardiogram
Electrocardiography
Euthanasia
Fat Emulsions, Intravenous - pharmacology
Heart - drug effects
Heart - physiopathology
Heart diseases
Heart Rate - drug effects
Intoxication
Lipids
Long QT Syndrome - blood
Long QT Syndrome - chemically induced
Long QT Syndrome - physiopathology
Long QT Syndrome - prevention & control
Magnesium sulfate
Magnesium Sulfate - pharmacology
Male
Medical research
Medicine, Experimental
Metoprolol
Metoprolol - pharmacology
Myocardium - metabolism
Myocardium - pathology
Natriuretic Peptide, Brain - blood
Peptide Fragments - blood
Pharmacology/Toxicology
Rats
Rats, Sprague-Dawley
Toxicity
Troponin
Troponin T - blood
Urea
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Summary:The aim of this study was to evaluate the effects of metoprolol, lipid emulsion and MgSO 4 which can be recommended for prevention of long QT that is one of the lethal consequences of amitriptyline intoxication. Thirty Sprague–Dawley male rats were included. Five groups respectively received the following: saline intraperitoneally (i.p.); amitriptyline (AMT) 100 mg/kg per os (p.o.) and saline i.p.; AMT 100 mg/kg p.o. and 5 mg/kg metoprolol i.p.; AMT 100 mg/kg p.o. and 20 ml/kg lipid emulsion i.p.; AMT 100 mg/kg p.o. and 75 mg/kg MgSO 4 i.p. After 1 h, all groups were analysed by ECG recordings in DII lead; their blood was taken for biochemical examination and euthanasia was performed. For histological examination, cardiac tissues were removed and sections were prepared. QTc was significantly reduced in treatment groups compared to the AMT+saline group. When compared with the AMT+saline, lipid emulsion did not affect pro-BNP and troponin levels in biochemical analysis, but it significantly reduced Caspase 3 expression in histological examination. In the group treated with AMT and metoprolol, there was no significant effect on Caspase 3 expression. In MgSO 4 -treated group, there was a significant decrease in troponin, pro-BNP and urea levels biochemically and significant decrease in Caspase 3 expression histologically when compared with the control group. With further studies including clinical studies, MgSO 4 , lipid emulsion or metoprolol may be used to improve AMT-induced cardiotoxicity. They can possibly become alternative approaches in the future for suicidal or accidental intoxication of tricyclic antidepressant in emergency departments.
ISSN:1530-7905
1559-0259
DOI:10.1007/s12012-018-9466-y