Facile synthesis of plasmonic zein nanoshells for imaging-guided photothermal cancer therapy

We demonstrate facile and green synthesis of gold deposited zein nanoshells (AuZNS) using environmental benign solvent ethanol. Water soluble glycol chitosan is used for stabilization as well as for cationic functionalization of zein nanoparticles. Gold deposition is performed via ex-situ method at...

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Bibliographic Details
Published in:Materials Science & Engineering C 2018-09, Vol.90, p.539-548
Main Authors: Chauhan, Deepak S., Arunkumar, P., Prasad, Rajendra, Mishra, Sumit Kumar, K. Reddy, B. Pradeep, De, Abhijit, Srivastava, Rohit
Format: Article
Language:English
Subjects:
Animals
Attenuation
Biocompatibility
Cancer
Cancer therapies
Cell Line, Tumor
Chemical synthesis
Chitosan
Contrast agents
Dosage
Ethanol
Gold
Gold - chemistry
Green synthesis
Humans
Hyperthermia, Induced
Iodine
Irradiation
Light therapy
Materials science
Medical imaging
Metal Nanoparticles - chemistry
Nanoparticles
Nanoshells - chemistry
Phototherapy
Photothermal therapy
Plasmonic nanoshells
Theranostic
Therapy
X-ray imaging
X-rays
Zein
Zein - chemistry
Zein nanoparticles
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Summary:We demonstrate facile and green synthesis of gold deposited zein nanoshells (AuZNS) using environmental benign solvent ethanol. Water soluble glycol chitosan is used for stabilization as well as for cationic functionalization of zein nanoparticles. Gold deposition is performed via ex-situ method at ambient conditions. AuZNS is of size around 100 nm and shows high inertness and biocompatibility even at double the therapeutic dosage. The absorbance is tuned at 808 nm for imaging-guided plasmonic photothermal therapy of cancer. Highly effective killing of cancer cells irrespective of their chemorefractory status is noticed at a very low therapeutic dosage of 25 μg and 5 min of biologically acceptable (500 mW) 808 nm laser irradiation. AuZNS also exhibit better X-ray attenuation in comparison to the commercially available iodine based contrast agent. [Display omitted] •Green synthesized and industrially scalable plasmonic zein nanoshells (AuZNS).•AuZNS for CT directed photothermal therapy of cancer.•Highly effective killing of cancer cells irrespective of their chemorefractory status
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2018.04.081