The logic of TGFβ signaling

The identification of the TGFβ cytokine signaling pathway, including membrane receptor serine/threonine kinases and Smad transcription factors as their substrates, has allowed the delineation of a process for conversion of these signals into programs of gene activation and repression that underlie c...

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Bibliographic Details
Published in:FEBS letters 2006-05, Vol.580 (12), p.2811-2820
Main Authors: Massagué, Joan, Gomis, Roger R.
Format: Article
Language:English
Subjects:
BMP
bone morphogenetic protein
Cancer
CDK
Cell cycle
Cyclin-dependent kinase
Cytostasis
Metastasis
Receptor serine/threonine kinase
Smad transcription factor
TGFβ
transforming growth factor β
Tumor suppressor
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Summary:The identification of the TGFβ cytokine signaling pathway, including membrane receptor serine/threonine kinases and Smad transcription factors as their substrates, has allowed the delineation of a process for conversion of these signals into programs of gene activation and repression that underlie critical cell fate and developmental decisions. The deconstruction of one of these responses – the cell cycle arrest response – into its elemental molecular parts has shed light into the mechanisms used by tumors to evade surveillance and cause metastasis.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2006.04.033