Diagnostic accuracy of plasma atrial natriuretic peptide concentrations in cats with and without cardiomyopathies

Plasma atrial natriuretic peptide (ANP) levels have been reported to be elevated in cats with cardiomyopathy. We investigated the diagnostic accuracy of plasma ANP concentration as an indicator of the severity of cardiomyopathies. This study included 78 control cats and 83 cats with various types of...

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Bibliographic Details
Published in:Journal of veterinary cardiology 2018-08, Vol.20 (4), p.234-243
Main Authors: Heishima, Y., Hori, Y., Nakamura, K., Yamashita, Y., Isayama, N., Kanno, N., Katagi, M., Onodera, H., Yamano, S., Aramaki, Y.
Format: Article
Language:English
Subjects:
Animals
Atrial Natriuretic Factor - blood
Cardiac biomarker
Cardiomyopathies - diagnosis
Cardiomyopathies - veterinary
Cat Diseases - diagnosis
Cats
Echocardiography - veterinary
Feline
Female
Heart Atria - diagnostic imaging
Heart disease
Heart failure
Heart Failure - diagnostic imaging
Heart Failure - veterinary
Hypertrophic cardiomyopathy
Male
Prospective Studies
Sensitivity and Specificity
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Summary:Plasma atrial natriuretic peptide (ANP) levels have been reported to be elevated in cats with cardiomyopathy. We investigated the diagnostic accuracy of plasma ANP concentration as an indicator of the severity of cardiomyopathies. This study included 78 control cats and 83 cats with various types of cardiomyopathy. This was a prospective multicentre study. Control cats were determined to have a normal heart, and diseased cats were diagnosed by echocardiography. Diseased cats were divided into asymptomatic cats without left atrial dilation (LAD), asymptomatic cats with LAD, and cats with heart failure. Plasma C-terminal ANP concentrations were measured using chemiluminescence. The median plasma ANP concentration in controls was 43.3 (interquartile range, 33.0–56.3) pg/mL. Plasma ANP values were significantly higher in the cardiomyopathic cats with LAD and heart failure, but the values in cats without LAD were comparable to those in control cats. To distinguish cats with cardiomyopathy from controls, a plasma ANP concentration >77.5 pg/mL afforded sensitivity of 66.3% and specificity of 84.6%. Use of plasma ANP concentration >110.9 pg/mL to identify cats with LAD had a sensitivity of 73.6% and specificity of 93.5%. The areas under the receiver-operating characteristic curve were 0.80 and 0.86. Plasma ANP concentrations were higher in cats with more advanced cardiomyopathy. Although assaying the ANP concentration alone may not help to diagnose cardiac disease, measuring provides additional information that is useful for assessing the severity of cardiomyopathies.
ISSN:1760-2734
1875-0834
DOI:10.1016/j.jvc.2018.04.008