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Risk Factors for Adverse Drug Events in Older Adults with Mobility Limitations in the Community Setting
OBJECTIVES: To investigate risk factors for self‐reported adverse drug events (ADEs) in a cohort of annually surveyed Iowa Medicare beneficiaries with mobility limitations. DESIGN: Prospective cohort study with baseline and two annual follow‐up questionnaires. SETTING: Population‐based sample of Iow...
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| Published in: | Journal of the American Geriatrics Society (JAGS) 2007-01, Vol.55 (1), p.29-34 |
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| container_end_page | 34 |
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| container_start_page | 29 |
| container_title | Journal of the American Geriatrics Society (JAGS) |
| container_volume | 55 |
| creator | Chrischilles, Elizabeth Rubenstein, Linda Van Gilder, Rachel Voelker, Margaret Wright, Kara Wallace, Robert |
| description | OBJECTIVES: To investigate risk factors for self‐reported adverse drug events (ADEs) in a cohort of annually surveyed Iowa Medicare beneficiaries with mobility limitations.
DESIGN: Prospective cohort study with baseline and two annual follow‐up questionnaires.
SETTING: Population‐based sample of Iowa Medicare beneficiaries with mobility limitations.
PARTICIPANTS: Members of the cohort with complete follow‐up questionnaires and prescription dispensing data (N=689).
MEASUREMENTS: The questionnaires asked about self‐reported ADEs in the previous 12 months, sociodemographic data, smoking, alcohol use, number of mobility limitations, and history of chronic disease. Pharmacy dispensing records were the source of number and classes of prescription drug use. Linked Medicare claims provided additional comorbidity data.
RESULTS: Of the 689 subjects, 151 (21.9%) reported an ADE, 83% of which resulted in physician contact and 56% of which resulted in discontinuing the medication. Number of different medications dispensed during the prior year was an independent predictor of a self‐reported ADE. Neither age, extent of mobility limitation, nor number of chronic conditions was independently associated with reporting an ADE.
CONCLUSION: Excess ADE risk observed with increasing mobility limitations is mediated through greater medication use. |
| doi_str_mv | 10.1111/j.1532-5415.2006.01034.x |
| format | article |
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DESIGN: Prospective cohort study with baseline and two annual follow‐up questionnaires.
SETTING: Population‐based sample of Iowa Medicare beneficiaries with mobility limitations.
PARTICIPANTS: Members of the cohort with complete follow‐up questionnaires and prescription dispensing data (N=689).
MEASUREMENTS: The questionnaires asked about self‐reported ADEs in the previous 12 months, sociodemographic data, smoking, alcohol use, number of mobility limitations, and history of chronic disease. Pharmacy dispensing records were the source of number and classes of prescription drug use. Linked Medicare claims provided additional comorbidity data.
RESULTS: Of the 689 subjects, 151 (21.9%) reported an ADE, 83% of which resulted in physician contact and 56% of which resulted in discontinuing the medication. Number of different medications dispensed during the prior year was an independent predictor of a self‐reported ADE. Neither age, extent of mobility limitation, nor number of chronic conditions was independently associated with reporting an ADE.
CONCLUSION: Excess ADE risk observed with increasing mobility limitations is mediated through greater medication use.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/j.1532-5415.2006.01034.x</identifier><identifier>PMID: 17233682</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>adverse drug event ; Age Factors ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Cohort Studies ; Depressive Disorder - complications ; Drug-Related Side Effects and Adverse Reactions ; Female ; General aspects ; Geriatrics ; Humans ; Iowa ; Logistic Models ; Male ; Medical sciences ; Medicare ; Miscellaneous ; Mobility ; Mobility Limitation ; Multivariate Analysis ; Older people ; Prescription drugs ; Prospective Studies ; psychomotor activity ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Surveys and Questionnaires</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2007-01, Vol.55 (1), p.29-34</ispartof><rights>2007 INIST-CNRS</rights><rights>2007, The American Geriatrics Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4934-16b76d82d55d3c9a86a10c018e02a1893ff662e8074d87e3bd0e60e68db0140a3</citedby><cites>FETCH-LOGICAL-c4934-16b76d82d55d3c9a86a10c018e02a1893ff662e8074d87e3bd0e60e68db0140a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1532-5415.2006.01034.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1532-5415.2006.01034.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,4043,27956,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18821006$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17233682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chrischilles, Elizabeth</creatorcontrib><creatorcontrib>Rubenstein, Linda</creatorcontrib><creatorcontrib>Van Gilder, Rachel</creatorcontrib><creatorcontrib>Voelker, Margaret</creatorcontrib><creatorcontrib>Wright, Kara</creatorcontrib><creatorcontrib>Wallace, Robert</creatorcontrib><title>Risk Factors for Adverse Drug Events in Older Adults with Mobility Limitations in the Community Setting</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>OBJECTIVES: To investigate risk factors for self‐reported adverse drug events (ADEs) in a cohort of annually surveyed Iowa Medicare beneficiaries with mobility limitations.
DESIGN: Prospective cohort study with baseline and two annual follow‐up questionnaires.
SETTING: Population‐based sample of Iowa Medicare beneficiaries with mobility limitations.
PARTICIPANTS: Members of the cohort with complete follow‐up questionnaires and prescription dispensing data (N=689).
MEASUREMENTS: The questionnaires asked about self‐reported ADEs in the previous 12 months, sociodemographic data, smoking, alcohol use, number of mobility limitations, and history of chronic disease. Pharmacy dispensing records were the source of number and classes of prescription drug use. Linked Medicare claims provided additional comorbidity data.
RESULTS: Of the 689 subjects, 151 (21.9%) reported an ADE, 83% of which resulted in physician contact and 56% of which resulted in discontinuing the medication. Number of different medications dispensed during the prior year was an independent predictor of a self‐reported ADE. Neither age, extent of mobility limitation, nor number of chronic conditions was independently associated with reporting an ADE.
CONCLUSION: Excess ADE risk observed with increasing mobility limitations is mediated through greater medication use.</description><subject>adverse drug event</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Depressive Disorder - complications</subject><subject>Drug-Related Side Effects and Adverse Reactions</subject><subject>Female</subject><subject>General aspects</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Iowa</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicare</subject><subject>Miscellaneous</subject><subject>Mobility</subject><subject>Mobility Limitation</subject><subject>Multivariate Analysis</subject><subject>Older people</subject><subject>Prescription drugs</subject><subject>Prospective Studies</subject><subject>psychomotor activity</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNkVFP2zAUhS20CTrgL0zWpO0t2bWdOO7DHlCBsq0MCZgm7cVyEqe4JDGzHWj__RxagbSnWZZs637n6vhchDCBlMT1eZWSnNEkz0ieUgCeAgGWpes9NHkpvEETAKCJ4CQ7QO-8XwEQCkLsowNSUMa4oBO0vDb-Hp-rKljncWMdPqkftfMan7phic8edR88Nj2-ams9Foc2vp9MuMOXtjStCRu8MJ0JKhjbP5PhTuOZ7bqhH4s3OgTTL4_Q20a1Xh_vzkP08_zsdnaRLK7mX2cni6TKpixLCC8LXgta53nNqqkSXBGogAgNVBExZU3DOdUCiqwWhWZlDZrHLeoSSAaKHaJP274Pzv4ZtA-yM77Sbat6bQcvKWR5IYBG8MM_4MoOro_eJI1hFrnIRkhsocpZ751u5IMznXIbSUCOk5ArOQYux8DlOAn5PAm5jtL3u_5D2en6VbiLPgIfd4DylWobp_rK-FdOiOgDeOS-bLkn0-rNfxuQ3-Y34y3qk63e-KDXL3rl7iUv4j_lrx9zOft-_fv2Ir-UwP4Cl1mx4A</recordid><startdate>200701</startdate><enddate>200701</enddate><creator>Chrischilles, Elizabeth</creator><creator>Rubenstein, Linda</creator><creator>Van Gilder, Rachel</creator><creator>Voelker, Margaret</creator><creator>Wright, Kara</creator><creator>Wallace, Robert</creator><general>Blackwell Publishing Inc</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>200701</creationdate><title>Risk Factors for Adverse Drug Events in Older Adults with Mobility Limitations in the Community Setting</title><author>Chrischilles, Elizabeth ; Rubenstein, Linda ; Van Gilder, Rachel ; Voelker, Margaret ; Wright, Kara ; Wallace, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4934-16b76d82d55d3c9a86a10c018e02a1893ff662e8074d87e3bd0e60e68db0140a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>adverse drug event</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Depressive Disorder - complications</topic><topic>Drug-Related Side Effects and Adverse Reactions</topic><topic>Female</topic><topic>General aspects</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Iowa</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicare</topic><topic>Miscellaneous</topic><topic>Mobility</topic><topic>Mobility Limitation</topic><topic>Multivariate Analysis</topic><topic>Older people</topic><topic>Prescription drugs</topic><topic>Prospective Studies</topic><topic>psychomotor activity</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chrischilles, Elizabeth</creatorcontrib><creatorcontrib>Rubenstein, Linda</creatorcontrib><creatorcontrib>Van Gilder, Rachel</creatorcontrib><creatorcontrib>Voelker, Margaret</creatorcontrib><creatorcontrib>Wright, Kara</creatorcontrib><creatorcontrib>Wallace, Robert</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chrischilles, Elizabeth</au><au>Rubenstein, Linda</au><au>Van Gilder, Rachel</au><au>Voelker, Margaret</au><au>Wright, Kara</au><au>Wallace, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors for Adverse Drug Events in Older Adults with Mobility Limitations in the Community Setting</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2007-01</date><risdate>2007</risdate><volume>55</volume><issue>1</issue><spage>29</spage><epage>34</epage><pages>29-34</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><notes>istex:CC1C7E9AF2616A6D424455D4AD9F1330F5C6276D</notes><notes>ark:/67375/WNG-CKRZTH5M-0</notes><notes>ArticleID:JGS1034</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>OBJECTIVES: To investigate risk factors for self‐reported adverse drug events (ADEs) in a cohort of annually surveyed Iowa Medicare beneficiaries with mobility limitations.
DESIGN: Prospective cohort study with baseline and two annual follow‐up questionnaires.
SETTING: Population‐based sample of Iowa Medicare beneficiaries with mobility limitations.
PARTICIPANTS: Members of the cohort with complete follow‐up questionnaires and prescription dispensing data (N=689).
MEASUREMENTS: The questionnaires asked about self‐reported ADEs in the previous 12 months, sociodemographic data, smoking, alcohol use, number of mobility limitations, and history of chronic disease. Pharmacy dispensing records were the source of number and classes of prescription drug use. Linked Medicare claims provided additional comorbidity data.
RESULTS: Of the 689 subjects, 151 (21.9%) reported an ADE, 83% of which resulted in physician contact and 56% of which resulted in discontinuing the medication. Number of different medications dispensed during the prior year was an independent predictor of a self‐reported ADE. Neither age, extent of mobility limitation, nor number of chronic conditions was independently associated with reporting an ADE.
CONCLUSION: Excess ADE risk observed with increasing mobility limitations is mediated through greater medication use.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17233682</pmid><doi>10.1111/j.1532-5415.2006.01034.x</doi><tpages>6</tpages></addata></record> |
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| issn | 0002-8614 1532-5415 |
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| subjects | adverse drug event Age Factors Aged Aged, 80 and over Biological and medical sciences Cohort Studies Depressive Disorder - complications Drug-Related Side Effects and Adverse Reactions Female General aspects Geriatrics Humans Iowa Logistic Models Male Medical sciences Medicare Miscellaneous Mobility Mobility Limitation Multivariate Analysis Older people Prescription drugs Prospective Studies psychomotor activity Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Surveys and Questionnaires |
| title | Risk Factors for Adverse Drug Events in Older Adults with Mobility Limitations in the Community Setting |
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