Risk Factors for Adverse Drug Events in Older Adults with Mobility Limitations in the Community Setting

OBJECTIVES: To investigate risk factors for self‐reported adverse drug events (ADEs) in a cohort of annually surveyed Iowa Medicare beneficiaries with mobility limitations. DESIGN: Prospective cohort study with baseline and two annual follow‐up questionnaires. SETTING: Population‐based sample of Iow...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Geriatrics Society (JAGS) 2007-01, Vol.55 (1), p.29-34
Main Authors: Chrischilles, Elizabeth, Rubenstein, Linda, Van Gilder, Rachel, Voelker, Margaret, Wright, Kara, Wallace, Robert
Format: Article
Language:English
Subjects:
adverse drug event
Age Factors
Aged
Aged, 80 and over
Biological and medical sciences
Cohort Studies
Depressive Disorder - complications
Drug-Related Side Effects and Adverse Reactions
Female
General aspects
Geriatrics
Humans
Iowa
Logistic Models
Male
Medical sciences
Medicare
Miscellaneous
Mobility
Mobility Limitation
Multivariate Analysis
Older people
Prescription drugs
Prospective Studies
psychomotor activity
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
Surveys and Questionnaires
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:OBJECTIVES: To investigate risk factors for self‐reported adverse drug events (ADEs) in a cohort of annually surveyed Iowa Medicare beneficiaries with mobility limitations. DESIGN: Prospective cohort study with baseline and two annual follow‐up questionnaires. SETTING: Population‐based sample of Iowa Medicare beneficiaries with mobility limitations. PARTICIPANTS: Members of the cohort with complete follow‐up questionnaires and prescription dispensing data (N=689). MEASUREMENTS: The questionnaires asked about self‐reported ADEs in the previous 12 months, sociodemographic data, smoking, alcohol use, number of mobility limitations, and history of chronic disease. Pharmacy dispensing records were the source of number and classes of prescription drug use. Linked Medicare claims provided additional comorbidity data. RESULTS: Of the 689 subjects, 151 (21.9%) reported an ADE, 83% of which resulted in physician contact and 56% of which resulted in discontinuing the medication. Number of different medications dispensed during the prior year was an independent predictor of a self‐reported ADE. Neither age, extent of mobility limitation, nor number of chronic conditions was independently associated with reporting an ADE. CONCLUSION: Excess ADE risk observed with increasing mobility limitations is mediated through greater medication use.
ISSN:0002-8614
1532-5415
DOI:10.1111/j.1532-5415.2006.01034.x