Comparative hazards of acute myocardial infarction among hospitalized patients with methamphetamine- or cocaine-use disorders: A retrospective cohort study

•Large cohort study of individuals with methamphetamine- or cocaine-use disorders.•Study tracked acute myocardial infarction (AMI) events for up to 16 years.•Competing risks analysis accounted for different patterns of death across cohorts.•Methamphetamine and cocaine groups had surprisingly “small”...

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Bibliographic Details
Published in:Drug and alcohol dependence 2018-07, Vol.188, p.259-265
Main Authors: Callaghan, Russell C., Halliday, Montana, Gatley, Jodi, Sykes, Jenna, Taylor, Lawren, Benny, Claire, Kish, Stephen J.
Format: Article
Language:English
Subjects:
Amphetamine-type stimulants
Appendicitis
Clinical variables
Cocaine
Cohort
Cohort analysis
Demographic variables
Demographics
Disorders
Drug abuse
Drug addiction
Drug use
Epidemiology
Hazards
Health hazards
Heart attacks
Hospitalization
Longitudinal
Methamphetamine
Myocardial infarction
Patients
Propensity
Recreational use
Risk
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Summary:•Large cohort study of individuals with methamphetamine- or cocaine-use disorders.•Study tracked acute myocardial infarction (AMI) events for up to 16 years.•Competing risks analysis accounted for different patterns of death across cohorts.•Methamphetamine and cocaine groups had surprisingly “small” increased AMI hazards.•First AMI hazard estimates in individuals with methamphetamine-use disorders. It is assumed that recreational use of methamphetamine can trigger acute myocardial infarction (AMI) events, but estimates of longitudinal hazards of AMI among methamphetamine users are lacking. Retrospective cohort study: Competing-risks analysis was used to estimate time-to-AMI patterns in methamphetamine versus matched appendicitis (population-proxy) and matched cocaine (drug-control) groups. Cohorts were propensity-score-matched using demographic and clinical variables. California, 1990–2005. Cohorts of individuals with no prior or concurrent history of AMI hospitalized with methamphetamine- (n = 73,056), cocaine- (n = 47,726), or appendicitis-related conditions (n = 330,109). ICD-9/ICD-10 indications of AMI (ICD-9 410.X; ICD-10 I21.X) in death records or inpatient hospital data. Patients in methamphetamine cohort were more likely to develop subsequent AMI in comparison to those in matched appendicitis cohort [Hazard ratio (HR): 1.41; 95% CI, 1.23–1.62, p 
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2018.03.030