The cuprizone model for demyelination

Background –  Important advances in multiple sclerosis (MS) research have been made as a direct or indirect result of experiments in animal models for the disease, although MS is a disease only affecting humans. The cuprizone model is a model for toxic demyelination. In this model, young mice are fe...

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Bibliographic Details
Published in:Acta neurologica Scandinavica 2008-05, Vol.117 (s188), p.72-76
Main Authors: Torkildsen, Ø., Brunborg, L. A., Myhr, K.-M., Bø, L.
Format: Article
Language:English
Subjects:
cuprizone
demyelination
multiple sclerosis
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Summary:Background –  Important advances in multiple sclerosis (MS) research have been made as a direct or indirect result of experiments in animal models for the disease, although MS is a disease only affecting humans. The cuprizone model is a model for toxic demyelination. In this model, young mice are fed with the copper chelator cuprizone, leading to oligodendrocyte death and a subsequent reversible demyelination. Spontaneous remyelination can be seen as early as 4 days after withdrawal of cuprizone. Materials and methods –  This article reviews previous research on this model and discusses the potential of the model for future application in MS research. Discussion –  The cuprizone model correlates with newer histopathological data in MS and is a valuable tool for studies on de‐ and remyelination. The use of the C57BL/6 strain offers the potential for future studies on transgene and knockout mice.
ISSN:0001-6314
1600-0404
DOI:10.1111/j.1600-0404.2008.01036.x