Structure and mechanism of bacterial tripartite efflux pumps

Efflux pumps are membrane proteins which contribute to multi-drug resistance. In Gram-negative bacteria, some of these pumps form complex tripartite assemblies in association with an outer membrane channel and a periplasmic membrane fusion protein. These tripartite machineries span both membranes an...

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Bibliographic Details
Published in:Research in microbiology 2018-09, Vol.169 (7-8), p.401-413
Main Authors: Neuberger, Arthur, Du, Dijun, Luisi, Ben F.
Format: Article
Language:English
Subjects:
Antibiotic resistance
Membrane proteins
Multi-drug efflux pumps
Tripartite assemblies
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Summary:Efflux pumps are membrane proteins which contribute to multi-drug resistance. In Gram-negative bacteria, some of these pumps form complex tripartite assemblies in association with an outer membrane channel and a periplasmic membrane fusion protein. These tripartite machineries span both membranes and the periplasmic space, and they extrude from the bacterium chemically diverse toxic substrates. In this chapter, we summarise current understanding of the structural architecture, functionality, and regulation of tripartite multi-drug efflux assemblies.
ISSN:0923-2508
1769-7123
DOI:10.1016/j.resmic.2018.05.003