Mild rhodium(iii)-catalyzed intramolecular annulation of benzamides with allylic alcohols to access azepinone derivatives

Azepinone derivatives are important frameworks of several natural products and bioactive compounds. They are synthetized using a Rh(iii)-catalyzed intramolecular annulation of benzamide-tethered allylic alcohols. The reaction requires mild conditions at room temperature and affords diversely substit...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (46), p.5891-5894
Main Authors: Peneau, Augustin, Tricart, Quentin, Guillou, Catherine, Chabaud, Laurent
Format: Article
Language:English
Subjects:
Alcohol
Alcohols
Benzamide
Chemical reactions
Derivatives
Natural products
Organic chemistry
Rhodium
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Summary:Azepinone derivatives are important frameworks of several natural products and bioactive compounds. They are synthetized using a Rh(iii)-catalyzed intramolecular annulation of benzamide-tethered allylic alcohols. The reaction requires mild conditions at room temperature and affords diversely substituted azepinones bearing a quaternary carbon.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc03319f