Potential of Aspergillus flavus genomics for applications in biotechnology

Aspergillus flavus is a common saprophyte and opportunistic pathogen that produces numerous secondary metabolites. The primary objectives of the A. flavus genomics program are to reduce and eliminate aflatoxin contamination in food and feed and to discover genetic factors that contribute to plant an...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2009-03, Vol.27 (3), p.151-157
Main Authors: Cleveland, Thomas E, Yu, Jiujiang, Fedorova, Natalie, Bhatnagar, Deepak, Payne, Gary A, Nierman, William C, Bennett, Joan W
Format: Article
Language:English
Subjects:
aflatoxins
Aflatoxins - genetics
Aspergillus flavus
Aspergillus flavus - physiology
biodegradation
Biological and medical sciences
Biology of microorganisms of confirmed or potential industrial interest
biomass
Biotechnology
Biotechnology - methods
carbohydrate metabolism
Chromosome Mapping - methods
Corn
Crop diseases
Fundamental and applied biological sciences. Psychology
Fungi
genes
Genetics
genome
Genome, Fungal - genetics
Genomics
Industrial Microbiology - trends
Internal Medicine
literature reviews
microbial genetics
microbial physiology
Mission oriented research
secondary metabolism
secondary metabolites
Signal Transduction - genetics
Studies
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Summary:Aspergillus flavus is a common saprophyte and opportunistic pathogen that produces numerous secondary metabolites. The primary objectives of the A. flavus genomics program are to reduce and eliminate aflatoxin contamination in food and feed and to discover genetic factors that contribute to plant and animal pathogenicity. A. flavus expressed sequence tags (ESTs) and whole-genome sequencing have been completed. Annotation of the A. flavus genome has revealed numerous genes and gene clusters that are potentially involved in the formation of aflatoxin and other secondary metabolites, as well as in the degradation of complex carbohydrate polymers. Analysis of putative secondary metabolism pathways might facilitate the discovery of new compounds with pharmaceutical properties, as well as new enzymes for biomass degradation.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2008.11.008