Distal Predominance of Electrodiagnostic Abnormalities in Early‐Stage Amyotrophic Lateral Sclerosis

ABSTRACT Introduction: In this study we compared the electrodiagnostic (EDX) yield of limb muscles in revealing lower motor neuron (LMN) dysfunction by electromyography (EMG) in early‐stage amyotrophic lateral sclerosis (ALS). Methods: This investigation was undertaken as a retrospective review at a...

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Bibliographic Details
Published in:Muscle & nerve 2018-09, Vol.58 (3), p.389-395
Main Authors: Shayya, Luay, Babu, Suma, Pioro, Erik P., Li, Jianbo, Li, Yuebing
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - diagnosis
Amyotrophic Lateral Sclerosis - physiopathology
Awaji criteria
Cohort Studies
denervation
Electrodiagnosis - methods
electromyography
Electromyography - methods
fasciculation
Female
Humans
Male
Middle Aged
Retrospective Studies
revised El Escorial criteria
Young Adult
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Summary:ABSTRACT Introduction: In this study we compared the electrodiagnostic (EDX) yield of limb muscles in revealing lower motor neuron (LMN) dysfunction by electromyography (EMG) in early‐stage amyotrophic lateral sclerosis (ALS). Methods: This investigation was undertaken as a retrospective review at a single center. Results: Our study included 122 consecutive patients with possible ALS, as defined by revised El Escorial criteria. Distal limb muscles showed more frequent EMG abnormalities than proximal muscles. EDX yield was found to be higher in the limb where weakness began and when clinical signs of LMN dysfunction were evident. Adoption of the Awaji criteria significantly increased the yield of EMG‐positive segments in the cervical (P 
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.26158