Neutrophil NETs: a novel contributor to preeclampsia-associated placental hypoxia?

Recent studies have suggested that the innate immune system is involved in the pathogenesis of preeclampsia. Its pathogenesis involves neutrophil activation and increased levels of cell-free DNA in the maternal plasma. Activation of neutrophils has recently been shown to induce DNA containing neutro...

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Bibliographic Details
Published in:Seminars in immunopathology 2007-06, Vol.29 (2), p.163-167
Main Authors: Gupta, Anurag Kumar, Hasler, Paul, Holzgreve, Wolfgang, Hahn, Sinuhe
Format: Article
Language:English
Subjects:
Bacteria
Blood pressure
Cell activation
Cytokines
Deoxyribonucleic acid
DNA
Endothelium
Female
Fetuses
Humans
Hypoxia
Immune system
Immunity, Innate
Innate immunity
Interleukin 8
Leukocytes
Leukocytes (neutrophilic)
Maternal-Fetal Exchange - immunology
Neutrophil Activation
Neutrophils
Neutrophils - immunology
Neutrophils - metabolism
Oxidative Stress
Pathogenesis
Pathogens
Perfusion
Placenta
Placenta - blood supply
Placenta - immunology
Placenta - metabolism
Pre-eclampsia
Pre-Eclampsia - immunology
Pre-Eclampsia - metabolism
Preeclampsia
Pregnancy
Proteins
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Summary:Recent studies have suggested that the innate immune system is involved in the pathogenesis of preeclampsia. Its pathogenesis involves neutrophil activation and increased levels of cell-free DNA in the maternal plasma. Activation of neutrophils has recently been shown to induce DNA containing neutrophil extracellular traps (NETs) which trap and kill bacteria. Massive NETs induction by the placentally derived factors (IL-8 and placental micro-debris) and their increased presence in preeclamptic placenta suggest that NETs might be involved in the pathogenesis of preeclampsia. Therefore, increased presence of NETs in preeclampsia may play a role in the deficient placental perfusion associated with this disorder.
ISSN:1863-2297
1863-2300
DOI:10.1007/s00281-007-0073-4