Analysis of cerebral blood flow and intracranial hypertension in critical patients with non-hepatic hyperammonemia

Hyperammonemia in adults is generally associated with cerebral edema, decreased cerebral metabolism, and increased cerebral blood flow. The aim of this study was to evaluate the association between non-hepatic hyperammonemia and intracranial hypertension assessed by Doppler flowmetry and measurement...

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Bibliographic Details
Published in:Metabolic brain disease 2018-08, Vol.33 (4), p.1335-1342
Main Authors: Larangeira, Alexandre Sanches, Tanita, Marcos Toshiyuki, Dias, Marcos Antonio, Filho, Olavo Franco Ferreira, Delfino, Vinicius Daher Alvares, Cardoso, Lucienne Tibery Queiroz, Grion, Cintia Magalhães Carvalho
Format: Article
Language:English
Subjects:
Adults
Ammonia
Arteries
Biochemistry
Biomedical and Life Sciences
Biomedicine
Blood flow
Blood pressure
Cerebral blood flow
Coma
Doppler effect
Edema
Flow velocity
Hospitals
Hyperammonemia
Hypertension
Intensive care units
Liver
Metabolic Diseases
Metabolism
Neurology
Neurosciences
Oncology
Optic nerve
Original Article
Patients
Sheaths
Ultrasound
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Summary:Hyperammonemia in adults is generally associated with cerebral edema, decreased cerebral metabolism, and increased cerebral blood flow. The aim of this study was to evaluate the association between non-hepatic hyperammonemia and intracranial hypertension assessed by Doppler flowmetry and measurement of the optic nerve sheath. A prospective cohort study in critically ill patients hospitalized in intensive care units of a University Hospital between March 2015 and February 2016. Clinical data and severity scores were collected and the Glasgow coma scale was recorded. Serial serum ammonia dosages were performed in all study patients. Transcranial Doppler evaluation was carried out for the first 50 consecutive results of each stratum of ammonemia: normal (
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-018-0245-z