The potential European genetic predisposition for non-contact anterior cruciate ligament injury

Purpose Previous research has provided evidence of a hereditary predisposition for anterior cruciate ligament (ACL) injury. The purpose of this study was to evaluate the association between ancestral population genetics and risk of non-contact ACL injuries. Methods Blood samples were collected from...

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Bibliographic Details
Published in:Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA sports traumatology, arthroscopy : official journal of the ESSKA, 2018-12, Vol.26 (12), p.3532-3536
Main Authors: Astur, Diego Costa, Andrade, Edilson, Arliani, Gustavo Gonçalves, Debieux, Pedro, Loyola, Leonor Casilla, dos Santos, Sidney Emanuel Batista, Burbano, Rommel Mario Rodriguez, Leal, Mariana Ferreira, Cohen, Moises
Format: Article
Language:English
Subjects:
Adult
Anterior cruciate ligament
Anterior Cruciate Ligament Injuries - genetics
Case-Control Studies
Continental Population Groups - genetics
Correlation analysis
Diagnostic systems
Female
Gene Frequency
Genetic analysis
Genetic markers
Genetic Predisposition to Disease
Genetics
Genotype
Health risks
Humans
INDEL Mutation
Injuries
Injury analysis
Knee
Knowledge base
Ligaments
Male
Markers
Medicine
Medicine & Public Health
Orthopedics
Polymerase Chain Reaction
Population genetics
Risk
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Summary:Purpose Previous research has provided evidence of a hereditary predisposition for anterior cruciate ligament (ACL) injury. The purpose of this study was to evaluate the association between ancestral population genetics and risk of non-contact ACL injuries. Methods Blood samples were collected from 177 individuals with a history of non-contact ACL injury and 556 non-injured control individuals for analysis of the genetic material through the use of a panel of 48 INDELs ancestry genetic markers from three ancestral origins. Results Among patients with non-contact ACL injury, 82% were male and 18% were female. In the control group, 78% were male, and 22% were female. The mean age of the non-contact ACL injury group was 31.7 years (± 10.2), and the control group was 33.8 years (± 13.2). The individual genetic contribution from INDELs of each ancestral origin varied considerably: ranging between 1.5–94.8% contribution for INDELs of African origin (mean of 21.4% of INDELs); between 2 and 96.1% contribution for INDELs of European origin (mean of 66.7% of INDELs); and between 1.3–96.4% contribution for INDELs of Amerindian origin (mean of 11.7% of INDELs). When comparing paired subjects from the non-contact ACL and control groups, the genetic analysis showed that the European ancestry score was higher in the non-contact ACL group than control group (0.70 ± 0.21 vs 0.63 ± 0.22 respectively, p  
ISSN:0942-2056
1433-7347
DOI:10.1007/s00167-018-4974-7