Pyridine-3-carboxamides as novel CB2 agonists for analgesia

We describe herein the medicinal chemistry approach which led to the discovery of a novel pyridine-3-carboxamide series of CB2 receptor agonists. The SAR of this new template was evaluated and culminated in the identification of analogue 14a which demonstrated efficacy in an in vivo model of inflamm...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2009, Vol.19 (1), p.259-263
Main Authors: MITCHELL, William L, GIBLIN, Gerard M. P, CLAYTON, Nick M, WILSON, Alex W, CHESSELL, Iain P, GREEN, Richard H, WHITTINGTON, Andrew R, WALL, Ian D, NAYLOR, Alan, EATHERTON, Andrew J, SLINGSBY, Brian P, RAWLINGS, Anthony D, JANDU, Karamjit S, HASLAM, Carl P, BROWN, Andrew J, GOLDSMITH, Paul
Format: Article
Language:English
Subjects:
Analgesics
Biological and medical sciences
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
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Summary:We describe herein the medicinal chemistry approach which led to the discovery of a novel pyridine-3-carboxamide series of CB2 receptor agonists. The SAR of this new template was evaluated and culminated in the identification of analogue 14a which demonstrated efficacy in an in vivo model of inflammatory pain.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2008.10.118