Ideal cardiovascular health and incidence of atherosclerotic cardiovascular disease among Chinese adults: the China-PAR project

Ideal cardiovascular health and incidence of atherosclerotic cardiovascular disease among Chinese adults: the China-PAR project

Existing evidence on the relationship between cardiovascular health (CVH) metrics and cardiovascular disease (CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD (ASCVD) in Chinese population. This stu...

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Bibliographic Details
Published in:Science China. Life sciences 2018-05, Vol.61 (5), p.504-514
Main Authors: Han, Chao, Liu, Fangchao, Yang, Xueli, Chen, Jichun, Li, Jianxin, Cao, Jie, Li, Ying, Shen, Chong, Yu, Ling, Liu, Zhendong, Wu, Xianping, Zhao, Liancheng, Hu, Dongshen, Lu, Xiangfeng, Wu, Xigui, Gu, Dongfeng
Format: Article
Language:eng
Subjects:
Arteriosclerosis
Atherosclerosis
Behavior modification
Biomedical and Life Sciences
Blood pressure
Cardiovascular disease
Cardiovascular diseases
Coronary artery disease
Cover Article
Death
Health risk assessment
Heart diseases
Life Sciences
Population studies
Public health
Regression analysis
Stroke
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Summary:Existing evidence on the relationship between cardiovascular health (CVH) metrics and cardiovascular disease (CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD (ASCVD) in Chinese population. This study was conducted among 93,987 adults from the China-PAR project (Prediction for ASCVD Risk in China) who were followed up until 2015. Cox proportional hazard regression models were used to estimate the hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) of CVH metrics for the risk of ASCVD, including coronary heart disease (CHD), stroke and ASCVD death. We further estimated the population-attributable risk percentage (PAR%) of these metrics in relation to each outcome. We observed gradient inverse associations between the number of ideal CVH metrics and ASCVD incidence. Compared with participants having ≤2 ideal CVH metrics, the multivariable-adjusted HRs (95% CIs) of ASCVD for those with 3, 4, 5, 6 and 7 ideal CVH metrics were 0.83 (0.74–0.93), 0.66 (0.59–0.74), 0.55 (0.48–0.61), 0.44 (0.38–0.50) and 0.24 (0.18–0.31), respectively (P for trend
ISSN:1674-7305
1869-1889