Belamchinenin A, an unprecedented tricyclic-fused triterpenoid with cytotoxicity from Belamcanda chinensis

Belamchinenin A (1), an unprecedented 6/5/6-fused tricyclic triterpenoid with a novel carbon skeleton, has been isolated from the rhizomes of Belamcanda chinensis. Compound 1 features a half-caged tricyclic nucleus with a flexible geranyl side chain. Its structure was determined by the interpretatio...

Full description

Saved in:
Bibliographic Details
Published in:Organic & biomolecular chemistry 2018, Vol.16 (20), p.3754-3759
Main Authors: Ni, Gang, Li, Jia-Yuan, Yu, De-Quan
Format: Article
Language:English
Subjects:
Absolute configuration
Belamcanda chinensis
Cytotoxicity
Nuclei
Nuclei (cytology)
Optimization
Rhizomes
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Belamchinenin A (1), an unprecedented 6/5/6-fused tricyclic triterpenoid with a novel carbon skeleton, has been isolated from the rhizomes of Belamcanda chinensis. Compound 1 features a half-caged tricyclic nucleus with a flexible geranyl side chain. Its structure was determined by the interpretation of spectroscopic data. The absolute configuration of tricyclic nucleus system of 1 was unequivocally assigned by ECD calculation. Geometries optimization indicated that the tricyclic nucleus system is rigid. Compound 1 showed cytotoxic activities against five cells with IC50 values from 2.29 to 4.47 μM.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob00789f