Magnetic resonance imaging based anatomical assessment of tongue impairment due to amyotrophic lateral sclerosis: A preliminary study

Amyotrophic Lateral Sclerosis (ALS) is a neurological disorder, which impairs tongue function for speech and swallowing. A widely used Diffusion Tensor Imaging (DTI) analysis pipeline is employed for quantifying differences in tongue fiber myoarchitecture between controls and ALS patients. This pipe...

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Bibliographic Details
Published in:The Journal of the Acoustical Society of America 2018-04, Vol.143 (4), p.EL248-EL254
Main Authors: Lee, Euna, Xing, Fangxu, Ahn, Sung, Reese, Timothy G., Wang, Ruopeng, Green, Jordan R., Atassi, Nazem, Wedeen, Van J., El Fakhri, Georges, Woo, Jonghye
Format: Article
Language:English
Subjects:
Adult
Aged
Amyotrophic Lateral Sclerosis - complications
Amyotrophic Lateral Sclerosis - pathology
Case-Control Studies
Diffusion Tensor Imaging
Female
Humans
Jasa Express Letters
Male
Middle Aged
Tongue Diseases - etiology
Tongue Diseases - pathology
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Description
Summary:Amyotrophic Lateral Sclerosis (ALS) is a neurological disorder, which impairs tongue function for speech and swallowing. A widely used Diffusion Tensor Imaging (DTI) analysis pipeline is employed for quantifying differences in tongue fiber myoarchitecture between controls and ALS patients. This pipeline uses both high-resolution magnetic resonance imaging (hMRI) and DTI. hMRI is used to delineate tongue muscles, while DTI provides indices to reveal fiber connectivity within and between muscles. The preliminary results using five controls and two patients show quantitative differences between the groups. This work has the potential to provide insights into the detrimental effects of ALS on speech and swallowing.
ISSN:0001-4966
1520-8524
DOI:10.1121/1.5030134