Evaluation of acute and subacute toxicities of aqueous ethanolic extract of leaves of Senna alata (L.) Roxb (Ceasalpiniaceae)

We investigated the acute and subacute toxicities of hydro-ethanolic extract of leaves of Senna alata (L.) Roxb. in Swiss mice and Wistar albino rats. The mice were divided into 6 groups of 10 animals and each group received once by intra-gastric gavages 0, 4, 8, 12, 16, 20 times 1000 mg/kg dose of...

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Bibliographic Details
Published in:African journal of biotechnology 2006-02, Vol.5 (3), p.283-289
Main Authors: Pieme, CA, Penlap, V N, Nkegoum, B, Taziebou, CL, Tekwu, E M, Etoa, F X, Ngongang, J
Format: Article
Language:English
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Summary:We investigated the acute and subacute toxicities of hydro-ethanolic extract of leaves of Senna alata (L.) Roxb. in Swiss mice and Wistar albino rats. The mice were divided into 6 groups of 10 animals and each group received once by intra-gastric gavages 0, 4, 8, 12, 16, 20 times 1000 mg/kg dose of extract. Distilled water served as the control. For the subacute toxicity, three groups of 10 rats (5 males and 5 females) were treated per os with distilled water (control), 500 or 1000 mg/kg of extract every 48 h for 26 days. At the end of treatment blood sample and 20% liver homogenates were collected for biochemical analyses. The results indicated that the medium lethal dose (LD sub(50)) was about 18.50 g/kg of body weight. Significant variation (P
ISSN:1684-5315
1684-5315