IFN-g down-regulates Secretoglobin 3A1 gene expression

STAT1 mediates Interferon (IFN)-dependent positive and negative regulation of inflammatory gene expression in lung. In this study, we examined the effect of IFN-g on the expression of SCGB3A1 which is thought to play crucial roles in inflammation and epithelial cell differentiation in lung. We found...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2009-02, Vol.379 (4), p.964-968
Main Authors: Yamada, A, Suzuki, D, Miyazono, A, Oshima, K, Kamiya, A, Zhao, B, Takami, M, Donnelly, R P, Itabe, H, Yamamoto, M, Kimura, S, Kamijo, R
Format: Article
Language:English
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Summary:STAT1 mediates Interferon (IFN)-dependent positive and negative regulation of inflammatory gene expression in lung. In this study, we examined the effect of IFN-g on the expression of SCGB3A1 which is thought to play crucial roles in inflammation and epithelial cell differentiation in lung. We found that expression of SCGB3A1 was down-regulated by IFN-g in a time- and dose-dependent manner in the murine transformed Clara Cells (mtCC) line. IFN-g induced the phosphorylation of STAT1, which binds to a STAT-binding element (SBE) in the SCGB3A1 gene promoter, leading to decreased transcriptional activation of this gene.
ISSN:0006-291X
DOI:10.1016/j.bbrc.2008.12.187