The smart approach: feasibility of lentigo maligna superficial margin assessment with hand‐held reflectance confocal microscopy technology

Background Lentigo maligna may be challenging to clear surgically. Objective To evaluate feasibility of using superficial skin cuts as RCM imaging anchors for attaining negative surgical margins in lentigo maligna. Methods Included patients presented with lentigo maligna near cosmetically sensitive...

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Bibliographic Details
Published in:Journal of the European Academy of Dermatology and Venereology 2018-10, Vol.32 (10), p.1687-1694
Main Authors: Pellacani, G., De Carvalho, N., Ciardo, S., Ferrari, B., Cesinaro, A.M., Farnetani, F., Bassoli, S., Guitera, P., Star, P., Rawson, R., Rossi, E., Magnoni, C., Gualdi, G., Longo, C., Scope, A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Dermatologic Surgical Procedures - methods
Feasibility Studies
Female
Humans
Hutchinson's Melanotic Freckle - diagnostic imaging
Hutchinson's Melanotic Freckle - pathology
Hutchinson's Melanotic Freckle - surgery
Male
Margins of Excision
Microscopy, Confocal - instrumentation
Middle Aged
Neoplasm, Residual
Observer Variation
Reproducibility of Results
Sensitivity and Specificity
Skin Neoplasms - diagnostic imaging
Skin Neoplasms - pathology
Skin Neoplasms - surgery
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Summary:Background Lentigo maligna may be challenging to clear surgically. Objective To evaluate feasibility of using superficial skin cuts as RCM imaging anchors for attaining negative surgical margins in lentigo maligna. Methods Included patients presented with lentigo maligna near cosmetically sensitive facial structures. We evaluated, with hand‐held‐RCM, microscopic clearance of melanoma beyond its dermoscopically detected edges. Evaluated margins were annotated using shallow skin cuts. If a margin was positive at ‘first‐step’ RCM evaluation, we sequentially advanced the margin radially outward at that segment by 2‐mm intervals until an RCM‐negative margin was identified. Prior to final surgical excision, we placed sutures at the outmost skin cuts to allow comparison of RCM and histopathological margin assessments. Primary outcome measure was histopathological verification that RCM‐negative margins were clear of melanoma. Results The study included 126 first‐step margin evaluations in 23 patients, median age 70 years (range: 43–91). Seventeen patients (74%) had primary in‐situ melanoma and six (26%) invasive melanoma, mean thickness 0.3 mm (range 0.2–0.4 mm). Six cases (26%) showed complete negative RCM margins on ‘first‐step’, 11 (48%) were negative at ‘second‐step’, and four (17%) at ‘third‐step’. In two additional cases (9%), margins clearance could not be determined via RCM due to widespread dendritic cells proliferation. The RCM‐negative margins in all 21 cases proved clear of melanoma on histopathology. Of the 15 cases that returned at 1‐year follow‐up, none showed any residual melanoma on dermoscopic and RCM examinations. Interobserver reproducibility showed fair agreement between bedside RCM reader and blinded remote‐site reader, with Spearman's rho of 0.48 and Cohen's kappa of 0.43; using bedside reader as reference, the remote reader's sensitivity was 92% and specificity 57% in positive margin detection. Conclusions Margin mapping of lentigo maligna with hand‐held‐RCM, using superficial skin cuts, appears feasible. This approach needs validation by larger studies.
ISSN:0926-9959
1468-3083
DOI:10.1111/jdv.15033