Effect of the synthetic resorcinol derivative of caryophyllene on cholesterol biosynthesis and the functional activity of immune system cells

The synthesis of a water-soluble compound belonging to the group of terpenoids-disodium salt of a resorcinol derivative of caryophyllene-is described. The biological properties of the new compound have been studied in mice in comparison to some native terpenoids and atorvastatin. The synthesized ter...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2006-10, Vol.40 (10), p.540-543
Main Authors: Kudinova, E. N., Salakhutdinov, N. F., Fomenko, V. V., Vol’skii, N. N., Perminova, O. M., Khoshchenko, O. N., Shwarts, Y. Ch, Dushkin, M. I.
Format: Article
Language:English
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Summary:The synthesis of a water-soluble compound belonging to the group of terpenoids-disodium salt of a resorcinol derivative of caryophyllene-is described. The biological properties of the new compound have been studied in mice in comparison to some native terpenoids and atorvastatin. The synthesized terpenoid (5 mg/mouse) decreases the rate of cholesterol biosynthesis in murine liver. Similar effects were observed for atorvastatin (0.2 mg/mouse) and the native terpenoids (8.5 mg/mouse), except for perillic alcohol (which produced a stimulating action). In addition, the obtained resorcinol derivative of caryophyllene inhibits mitogen-stimulated murine splenic cell proliferation in vitro in a dose-dependent manner. The drug efficacy in this reaction is comparable with that of perillic alcohol and alpha -terpineol, while being less pronounced than the effect of dipentene and atorvastatin.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-006-0188-2