Recovery of biotechnological products using aqueous two phase systems

Aqueous two-phase system (ATPS) has been suggested as a promising separation tool in the biotechnological industry. This liquid-liquid extraction technique represents an interesting advance in downstream processing due to several advantages such as simplicity, rapid separation, efficiency, economy,...

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Bibliographic Details
Published in:Journal of bioscience and bioengineering 2018-09, Vol.126 (3), p.273-281
Main Authors: Phong, Win Nee, Show, Pau Loke, Chow, Yin Hui, Ling, Tau Chuan
Format: Article
Language:English
Subjects:
Aqueous two-phase system
Biotechnological products
Biotechnology - methods
Downstream processing
Green Chemistry Technology - methods
Liquid-Liquid Extraction - methods
Liquid-liquid extraction technique
Polyethylene Glycols - chemistry
Recovery
Recycling
Water - chemistry
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Summary:Aqueous two-phase system (ATPS) has been suggested as a promising separation tool in the biotechnological industry. This liquid-liquid extraction technique represents an interesting advance in downstream processing due to several advantages such as simplicity, rapid separation, efficiency, economy, flexibility and biocompatibility. Up to date, a range of biotechnological products have been successfully recovered from different sources with high yield using ATPS-based strategy. In view of the important potential contribution of the ATPS in downstream processing, this review article aims to provide latest information about the application of ATPS in the recovery of various biotechnological products in the past 7 years (2010–2017). Apart from that, the challenges as well as the possible future work and outlook of the ATPS-based recovery method have also been presented in this review article.
ISSN:1389-1723
1347-4421
DOI:10.1016/j.jbiosc.2018.03.005