Better Selection Criteria With Prognostic Factors for Liver Transplantation

Liver transplantation has evolved significantly in recent years, with each advancement part of the effort toward increasing patient and graft survival as well as quality of life. The objective of this study was to evaluate the prognostic factors and selection criteria for liver transplantation. Our...

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Bibliographic Details
Published in:	Transplantation proceedings 2018-04, Vol.50 (3), p.766-768
Main Authors:	Nacif, L.S., Pinheiro, R.S., Rocha-Santos, V., Barbosa, V.M., de Moura Dias, A.P., Martino, R.B., Macedo, R.A., Ducatti, L., Haddad, L., Galvão, F., Andraus, W., Carneiro D’ Albuquerque, L.
Format:	Article
Language:	eng
Subjects:	Adult Female Graft Survival Humans Liver Failure - physiopathology Liver Failure - surgery Liver Transplantation - methods Liver Transplantation - mortality Logistic Models Male Middle Aged Patient Selection Prognosis Retrospective Studies Tissue and Organ Procurement - methods
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Summary:	Liver transplantation has evolved significantly in recent years, with each advancement part of the effort toward increasing patient and graft survival as well as quality of life. The objective of this study was to evaluate the prognostic factors and selection criteria for liver transplantation. Our study was a statistical analysis, logistic regression, and survival evaluation of a total of 80 liver transplants that were performed between June 1, 2016 and September 24, 2016. Recipient factors evaluated included age, retransplantation, hemodialysis, cardiac risk, portal vein thrombosis, hospitalization, fulminant hepatitis, previous surgery, renal failure, and Model for End-stage Liver Disease (MELD) score. Donor factors included age, cardiac arrest, acidosis, days in the intensive care unit, steatosis, and vasoactive drug use. Of the 80 patients transplanted, 65 deceased donor liver transplants (DDLTs) and 15 living donor liver transplants (LDLTs) were performed. LDLT overall 1-year patient survival was 77.5% and graft survival 75%, and DDLT overall patient survival was 89.23% and graft survival was 86.15%. On evaluated score criteria analyzed we observed a significant score on recipient (P = .01) and not significant on donor (P =.45). Isolated factors evaluated included recipient age (relative risk [RR] 3.15, 95% confidence interval [CI] 0.89 to 11.09; P = .074), retransplant (RR 4.22, 95% CI 1.36 to 13.1; P = .013), and hemodialysis (RR 4.23, 95% CI 1.45 to 12.31, P = .008). On donor evaluation, we observed moderate and severe steatosis (RR 3.8, 95% CI 0.86 to 16.62; P = .06). In conclusion, we demonstrate a relevant model of criteria selection of liver transplant patients that is able to make a better match between the donor and recipient allocation for a better graft and patient survival.
ISSN:	0041-1345 1873-2623