Mortality in patients with permanent hypoparathyroidism after total thyroidectomy

Background Permanent hypoparathyroidism remains the most common adverse outcome after total thyroidectomy, but long‐term effects of hypoparathyroidism are unknown. The aim was to investigate mortality in patients with permanent hypoparathyroidism after total thyroidectomy. Methods Data from the Scan...

Full description

Saved in:
Bibliographic Details
Published in:British journal of surgery 2018-09, Vol.105 (10), p.1313-1318
Main Authors: Almquist, M., Ivarsson, K., Nordenström, E., Bergenfelz, A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Female
Follow-Up Studies
Health risk assessment
Humans
Hypoparathyroidism - etiology
Hypoparathyroidism - mortality
Kaplan-Meier Estimate
Male
Middle Aged
Mortality
Postoperative Complications - mortality
Proportional Hazards Models
Registries
Sweden
Thyroid gland
Thyroidectomy
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Permanent hypoparathyroidism remains the most common adverse outcome after total thyroidectomy, but long‐term effects of hypoparathyroidism are unknown. The aim was to investigate mortality in patients with permanent hypoparathyroidism after total thyroidectomy. Methods Data from the Scandinavian Quality Register for Thyroid, Parathyroid and Adrenal Surgery were linked with the Swedish National Prescription Register for Pharmaceuticals and the Swedish National Inpatient Register. Patients who underwent total thyroidectomy between 1 July 2005 and 30 June 2014 for benign thyroid disease, and who used active vitamin D for at least 6 months after surgery, were classified as having permanent hypoparathyroidism and included in the study cohort. Risk of death was assessed using Cox regression analysis, adjusting for age, sex, thyrotoxicosis and co‐morbidity. Results There were 4899 patients, with a mean(s.d.) age of 46·3(15·8) years; 83·1 per cent were women, and 2932 patients (59·8 per cent) had thyrotoxicosis. In all, 246 patients (5·2 per cent) were classified as having permanent hypoparathyroidism. Mean(s.d.) follow‐up was 4·4(2·4) years, and 109 patients (2·2 per cent) died during follow‐up. Compared with patients without permanent hypoparathyroidism, the risk of death was significantly higher among patients with permanent hypoparathyroidism after total thyroidectomy (adjusted hazard ratio 2·09, 95 per cent c.i. 1·04 to 4·20). Conclusion Permanent hypoparathyroidism after total thyroidectomy for benign disease is common and associated with an increased risk of death. Higher than expected
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.10843