The robustness of T2 value as a trabecular structural index at multiple spatial resolutions of 7 Tesla MRI

Purpose To evaluate the robustness of MR transverse relaxation times of trabecular bone from spin‐echo and gradient‐echo acquisitions at multiple spatial resolutions of 7 T. Methods The effects of MRI resolutions to T2 and T2* of trabecular bone were numerically evaluated by Monte Carlo simulations....

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Bibliographic Details
Published in:Magnetic resonance in medicine 2018-11, Vol.80 (5), p.1949-1961
Main Authors: Lee, D.K., Song, Y.K., Park, B.W., Cho, H.P., Yeom, J.S., Cho, G., Cho, H.
Format: Article
Language:English
Subjects:
Bone marrow
Cancellous bone
Computed tomography
Computer simulation
Correlation
Degradation
Femur
Image processing
Image segmentation
Knee
Magnetic resonance imaging
magnetic resonance relaxations
magnetic resonance spatial resolution
Medical imaging
Robustness (mathematics)
Spatial discrimination
Spatial resolution
trabecular structure
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Summary:Purpose To evaluate the robustness of MR transverse relaxation times of trabecular bone from spin‐echo and gradient‐echo acquisitions at multiple spatial resolutions of 7 T. Methods The effects of MRI resolutions to T2 and T2* of trabecular bone were numerically evaluated by Monte Carlo simulations. T2, T2*, and trabecular structural indices from multislice multi‐echo and UTE acquisitions were measured in defatted human distal femoral condyles on a 7 T scanner. Reference structural indices were extracted from high‐resolution microcomputed tomography images. For bovine knee trabecular samples with intact bone marrow, T2 and T2* were measured by degrading spatial resolutions on a 7 T system. Results In the defatted trabecular experiment, both T2 and T2* values showed strong ( |r| > 0.80) correlations with trabecular spacing and number, at a high spatial resolution of 125 µm3. The correlations for MR image‐segmentation‐derived structural indices were significantly degraded ( |r|  0.95 with respect to approximately 0.4 mm3, 11 minutes) and maintained consistent correlations ( |r| > 0.70) with respect to trabecular spacing (turbo spin echo, 22.5 minutes). Conclusion T2 measurements of trabeculae at 7 T are robust with degrading spatial resolution and may be preferable in assessing trabecular spacing index with reduced scan time, when high‐resolution 3D micro‐MRI is difficult to obtain.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.27202