Mitochondria, glycogen, and lipid droplets in skeletal muscle during testosterone treatment and strength training: a randomized, double‐blinded, placebo‐controlled trial

Summary Low testosterone levels in aging men are associated with insulin resistance. Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle. In this randomized, double‐blinded, placebo‐controlled study, we investigated th...

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Bibliographic Details
Published in:Andrology (Oxford) 2018-07, Vol.6 (4), p.547-555
Main Authors: Jensen, R. C., Christensen, L. L., Nielsen, J., Schrøder, H. D., Kvorning, T., Gejl, K., Højlund, K., Glintborg, D., Andersen, M.
Format: Article
Language:English
Subjects:
Aged
Aging
Body Composition - drug effects
Body fat
Double-Blind Method
Glycogen
Hormone Replacement Therapy
Humans
Insulin Resistance
Lipid Droplets - drug effects
Lipids
Male
Males
metabolism
Middle Aged
Mitochondria
Mitochondria - drug effects
Muscle, Skeletal - drug effects
Musculoskeletal system
Resistance Training
skeletal muscle
Sports training
Strength training
Testosterone
Testosterone - therapeutic use
testosterone replacement therapy
transmission electron microscopy
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Summary:Summary Low testosterone levels in aging men are associated with insulin resistance. Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle. In this randomized, double‐blinded, placebo‐controlled study, we investigated the effects of six‐month testosterone replacement therapy (TRT) and strength training (ST) on mitochondrial, glycogen, and lipid droplet (LD) content in skeletal muscle of aging men with subnormal bioavailable testosterone (BioT) levels. Mitochondrial, glycogen, and LD volume fractions in muscle biopsies were estimated by transmission electron microscopy. Insulin sensitivity (insulin‐stimulated Rd) and body composition were assessed by euglycemic‐hyperinsulinemic clamp and dual X‐ray absorptiometry, respectively. TRT significantly increased total testosterone levels, BioT, and lean body mass (LBM) (p 
ISSN:2047-2919
2047-2927
DOI:10.1111/andr.12492