Genetic and environmental determinants of risk for cholangiocarcinoma via Opisthorchis viverrini in a densely infested area in Nakhon Phanom, northeast Thailand

Infection with Opisthorchis viverrini (OV) is associated with cholangiocarcinoma. OV is common in northeast Thailand, but less than 10% of the inhabitants develop cholangiocarcinoma. Animal experiments suggest that OV infection alone does not cause cholangiocarcinoma, and thus other environmental an...

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Bibliographic Details
Published in:International journal of cancer 2005-12, Vol.117 (5), p.854-860
Main Authors: Honjo, Satoshi, Srivatanakul, Petcharin, Sriplung, Hutcha, Kikukawa, Hiroko, Hanai, Shuji, Uchida, Kazuhiko, Todoroki, Takeshi, Jedpiyawongse, Adisorn, Kittiwatanachot, Pacharin, Sripa, Banchob, Deerasamee, Somyos, Miwa, Masanao
Format: Article
Language:English
Subjects:
alcohol drinking
Animals
Base Sequence
Biological and medical sciences
Cholangiocarcinoma - epidemiology
Cholangiocarcinoma - parasitology
DNA Primers
Gastroenterology. Liver. Pancreas. Abdomen
Humans
inflammation
Life Style
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
nitrosamine
Opisthorchiasis - complications
Opisthorchiasis - epidemiology
Opisthorchis - isolation & purification
Opisthorchis viverrini
polymorphism
population‐based case‐control study
Risk Factors
Thailand - epidemiology
Tropical medicine
Tumors
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Summary:Infection with Opisthorchis viverrini (OV) is associated with cholangiocarcinoma. OV is common in northeast Thailand, but less than 10% of the inhabitants develop cholangiocarcinoma. Animal experiments suggest that OV infection alone does not cause cholangiocarcinoma, and thus other environmental and genetic factors may play a role in causation. We conducted a population‐based case‐control study in which sex, age and place of residence were matched individually. Polymorphisms of GSTM1 and GSTT1 alone were not associated with risk for cholangiocarcinoma, while an elevated level of antibodies against OV (ELISA) ≥0.200 was the strongest risk indicator (odds ratio as compared to that
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.21146