Lung Ultrasound and Microbubbles Enhance Aminoglycoside Efficacy and Delivery to the Lung in Escherichia coli-induced Pneumonia and Acute Respiratory Distress Syndrome

To the Editor: Acute respiratory distress syndrome (ARDS) is a devastating disorder characterized by lung microvascular leakage leading to pulmonary edema and hypoxemia (1). [...]developing an easy and safe method to increase the therapeutic index of aminoglycosides specifically in the lungs would b...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2018-08, Vol.198 (3), p.404-408
Main Authors: Sugiyama, Michael G, Mintsopoulos, Victoria, Raheel, Hira, Goldenberg, Neil M, Batt, Jane E, Brochard, Laurent, Kuebler, Wolfgang M, Leong-Poi, Howard, Karshafian, Raffi, Lee, Warren L
Format: Article
Language:English
Subjects:
Antibiotics
Cavitation
Drug dosages
E coli
Edema
Lungs
Permeability
Pneumonia
Respiratory distress syndrome
Ultrasonic imaging
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Summary:To the Editor: Acute respiratory distress syndrome (ARDS) is a devastating disorder characterized by lung microvascular leakage leading to pulmonary edema and hypoxemia (1). [...]developing an easy and safe method to increase the therapeutic index of aminoglycosides specifically in the lungs would be of great practical value. Thirty minutes after USMB, gentamicin concentrations in both BAL and lung tissue were significantly higher (at least twofold) in USMB-treated animals than in gentamicin-alone control animals (Figures 2B and 2C). [...]USMB enhanced antibiotic delivery and bacterial killing. Supported by the Canadian Institutes of Health Research (MOP 130564 [W.L.L.]), the Canada Foundation for Innovation (CFI 34769 [W.L.L.]), a Natural Sciences and Engineering Research Council (NSERC) of Canada Engage award (503493-16 [W.L.L.]), and an Ontario Centres of Excellence Voucher for Innovation and Productivity I award (OCE-VIP1 28176 [W.L.L.]).
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201711-2259le