Oxygen management in mechanically ventilated patients: A multicenter prospective observational study

To observe arterial oxygen in relation to fraction of inspired oxygen (FIO2) during mechanical ventilation (MV). In this multicenter prospective observational study, we included adult patients required MV for >48h during the period from March to May 2015. We obtained FIO2, PaO2 and SaO2 from comm...

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Bibliographic Details
Published in:Journal of critical care 2018-08, Vol.46, p.1-5
Main Authors: Egi, Moritoki, Kataoka, Jun, Ito, Takashi, Nishida, Osamu, Yasuda, Hideto, Okamaoto, Hiroshi, Shimoyama, Akira, Izawa, Masayo, Matsumoto, Shinsaku, Furushima, Nana, Yamashita, Shigeki, Takada, Koji, Ohtsuka, Masahide, Fujisaki, Noritomo, Shime, Nobuaki, Inagaki, Nobuhiro, Taira, Yasuhiko, Yatabe, Tomoaki, Nitta, Kenichi, Yokoyama, Takeshi, Kushimoto, Shigeki, Tokunaga, Kentaro, Doi, Matsuyuki, Masuda, Takahiro, Miki, Yasuo, Matsuda, Kenichi, Asaga, Takehiko, Hazama, Keita, Matsuyama, Hiroki, Nishimura, Masaji, Mizobuchi, Satoshi
Format: Article
Language:English
Subjects:
Airway management
Arterial oxygen
Fraction of inspired oxygen
Hyperoxemia
Hyperoxia
Intensive care
Mechanical ventilation
Mortality
Multicenter
Observational studies
Oxygen therapy
Patients
Prospective
Ventilators
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Summary:To observe arterial oxygen in relation to fraction of inspired oxygen (FIO2) during mechanical ventilation (MV). In this multicenter prospective observational study, we included adult patients required MV for >48h during the period from March to May 2015. We obtained FIO2, PaO2 and SaO2 from commencement of MV until the 7th day of MV in the ICU. We included 454 patients from 28 ICUs in this study. The median APACHE II score was 22. Median values of FIO2, PaO2 and SaO2 were 0.40, 96mmHg and 98%. After day two, patients spent most of their time with a FIO2 between 0.3 and 0.49 with median PaO2 of approximately 90mmHg and SaO2 of 97%. PaO2 was ≥100mmHg during 47.2% of the study period and was ≥130mmHg during 18.4% of the study period. FIO2 was more likely decreased when PaO2 was ≥130mmHg or SaO2 was ≥99% with a FIO2 of 0.5 or greater. When FIO2 was
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2018.03.024