Association of Plasma Irisin with Bone Mineral Density in a Large Chinese Population Using an Extreme Sampling Design

Irisin, a myokine produced by skeletal muscle in response to physical exercise, promotes trans-differentiation of white adipose tissue into brown adipose tissue. Recent evidences suggested that irisin also plays an important role in the control of bone metabolism. This study aimed to ascertain the r...

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Published in:Calcified tissue international 2018-09, Vol.103 (3), p.246-251
Main Authors: Wu, Long-Fei, Zhu, Dong-Cheng, Tang, Chang-Hua, Ge, Bing, Shi, Ju, Wang, Bing-Hua, Lu, Yi-Hua, He, Pei, Wang, Wen-Yu, Lu, Si-Qi, Zhong, Jiao, Zhou, Xu, Zhu, Kan, Ji, Wen, Gao, Hong-Qin, Gu, Hong-Bo, Mo, Xing-Bo, Lu, Xin, Zhang, Lei, Zhang, Yong-Hong, Deng, Fei-Yan, Lei, Shu-Feng
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose tissue (brown)
Aged
Asian Continental Ancestry Group
Biochemistry
Biomedical and Life Sciences
Bone density
Bone Density - physiology
Bone mineral density
Bone turnover
Cell Biology
Cholesterol
Collagen
Endocrinology
Enzyme-linked immunosorbent assay
Female
Fibronectins - blood
Geriatrics
Hip
Humans
Life Sciences
Male
Males
Original Research
Orthopedics
Osteoporosis
Plasma
Population
Population density
Sampling
Sex Characteristics
Skeletal muscle
Triglycerides
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Summary:Irisin, a myokine produced by skeletal muscle in response to physical exercise, promotes trans-differentiation of white adipose tissue into brown adipose tissue. Recent evidences suggested that irisin also plays an important role in the control of bone metabolism. This study aimed to ascertain the relationship between plasma irisin and bone mineral density (BMD) in Chinese population by adoption of an extreme sampling method. Based on a large and screened Chinese elderly population ( N  = 6308), two subgroups with extremely high and low hip BMD were selected for discovery ( N  = 80, high vs. low BMD = 44:36) and validation ( N  = 60, high vs. low BMD = 30:30), respectively. Plasma irisin, P1NP, and β-CTx were measured using commercially available ELISA kits. Other metabolic parameters (e.g., blood glucose, total cholesterol and triglycerides) were collected. Student’s t test and Spearman correlation analyses were conducted in SPSS. Significant difference was discovered for plasma irisin between females and age-matched males ( N  = 80, male vs. female = 42:38, P  = 0.002). The plasma irisin levels were significantly higher in high BMD subjects than in low BMD subjects, which was observed in both discovery ( P  = 0.012) and validation samples ( P  = 0.022). However, such observation was limited to males only. Further correlation analyses in males showed that plasma irisin was correlated with BMD ( r  = 0.362, P  = 0.025) and triglyceride ( r  = − 0.354, P  = 0.032). Plasma irisin levels were associated with hip BMD in Chinese elderly men. This study represented the first effort of investigating the relationship of plasma irisin and BMD in elderly population. The positive correlation between plasma irisin and BMD hints intrinsic communication between muscle and bone.
ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-018-0415-3