Assessment of Cardiac Vegetative Control during Acute Graduated Exogenous Normobaric Hypoxia in Rats

The effects of exogenous normobaric hypoxic hypoxia on vegetative control of the heart and BP were examined in Wistar rats. The reference ranges of variation pulsometry parameters were determined in rats with normoxemia for 3 physiological variants of autonomic homeostasis: eutony, sympathicotony, a...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-03, Vol.164 (5), p.591-595
Main Authors: Kotel’nikov, V. N., Osipov, I. O., Zayats, Yu. V., Gel’tser, B. I.
Format: Article
Language:English
Subjects:
Autonomic nervous system
Biomedical and Life Sciences
Biomedicine
Cell Biology
Control systems
Heart
Heart diseases
Heart rate
Homeostasis
Hypotension
Hypoxemia
Hypoxia
Internal Medicine
Laboratory Medicine
Nervous system
Oxygenation
Pathology
Physiological aspects
Rodents
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Summary:The effects of exogenous normobaric hypoxic hypoxia on vegetative control of the heart and BP were examined in Wistar rats. The reference ranges of variation pulsometry parameters were determined in rats with normoxemia for 3 physiological variants of autonomic homeostasis: eutony, sympathicotony, and vagotony. Most rats (80%) demonstrated autonomic eutony. The study showed that saturation of arterial blood with oxygen is the most adequate assessment of severity of acute exogenous normobaric hypoxic hypoxia progressing within a closed hypoxic chamber, which standardizes this method and minimizes inaccuracies resulting from individual sensitivity to hypoxic stress. The changes in functional activity of systems that control the heart rhythm closely correlated with the drop in arterial blood oxygenation. While a small arterial hypoxemia activated the ergotropic elements of autonomic nervous system central subdivision accompanied by elevation of systolic BP, the moderate hypoxemia augmented the cholinergic influences and moderated the adrenergic ones under maintaining mobilization of the central autonomic nervous system-control loop and normotension. Severe hypoxemia was manifested by augmented influences from autonomic nervous system central subdivisions on the heart rate, disadaptation of the control systems, and systolic - diastolic arterial hypotension.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4038-5