Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects

Broccoli sprouts represent an interesting choice of healthy food product as they are rich in glucosinolates and their cognate bioactive metabolites, isothiocyanates able to counteract the negative effects of diverse pathologies. As obesity is linked to an inflammatory component, the aim of the study...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2019-04, Vol.38 (2), p.745-752
Main Authors: López-Chillón, María Teresa, Carazo-Díaz, Carmen, Prieto-Merino, David, Zafrilla, Pilar, Moreno, Diego A., Villaño, Débora
Format: Article
Language:English
Subjects:
Adult
Bioavailability
Biomarkers - blood
Brassica
Brassica oleracea
Cytokines - blood
Diet - methods
Female
Follow-Up Studies
Glucosinolates
Glucosinolates - blood
Humans
IL-6
Inflammation
Inflammation - blood
Interleukin-6 - blood
Isothiocyanates - blood
Male
Middle Aged
Overweight - diet therapy
Overweight - physiopathology
Sulforaphane
Vegetables
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Summary:Broccoli sprouts represent an interesting choice of healthy food product as they are rich in glucosinolates and their cognate bioactive metabolites, isothiocyanates able to counteract the negative effects of diverse pathologies. As obesity is linked to an inflammatory component, the aim of the study was to evaluate the anti-inflammatory action of broccoli sprouts in overweight adult subjects. An in vivo controlled study was performed in 40 healthy overweight subjects (ClinicalTrials.gov ID NCT 03390855). Treatment phase consisted on the consumption of broccoli sprouts (30 g/day) during 10 weeks and the follow-up phase of 10 weeks of normal diet without consumption of these broccoli sprouts. Anthropometric parameters as body fat mass, body weight, and BMI were determined. Inflammation status was assessed by measuring levels of TNF-α, IL-6, IL-1β and C-reactive protein. IL-6 levels significantly decreased (mean values from 4.76 pg/mL to 2.11 pg/mL with 70 days of broccoli consumption, p 
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2018.03.006