Post-progression survival following second-line chemotherapy in patients with advanced pancreatic cancer previously treated with gemcitabine: a meta-analysis

Summary Background Post-progression survival (PPS) could be a confounding element in interpreting data from clinical trials of second-line chemotherapy in patients with advanced pancreatic cancer (PC) previously treated with gemcitabine (GEM) because a recent meta-analysis of oxaliplatin combination...

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Bibliographic Details
Published in:Investigational new drugs 2018-10, Vol.36 (5), p.939-948
Main Authors: Kasuga, Akiyoshi, Hamamoto, Yasuo, Takeuchi, Ayano, Okano, Naohiro, Togasaki, Kazuhiro, Aoki, Yu, Suzuki, Takeshi, Kawasaki, Kenta, Hirata, Kenro, Sukawa, Yasutaka, Kanai, Takanori, Takaishi, Hiromasa
Format: Article
Language:English
Subjects:
Cancer
Chemotherapy
Clinical trials
Gemcitabine
Median (statistics)
Medical research
Medicine
Medicine & Public Health
Meta-analysis
Oncology
Oxaliplatin
Pancreatic cancer
Patients
Pharmacology/Toxicology
Review
Salvage
Studies
Survival
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Summary:Summary Background Post-progression survival (PPS) could be a confounding element in interpreting data from clinical trials of second-line chemotherapy in patients with advanced pancreatic cancer (PC) previously treated with gemcitabine (GEM) because a recent meta-analysis of oxaliplatin combination therapy showed statistical heterogeneity for overall survival (OS) but not for progression-free survival (PFS). This study aimed to improve the understanding of the impact of PPS on OS in this setting. Methods Databases were searched to identify randomized controlled trials (RCTs) in the salvage setting. We evaluated relationships between OS and PFS, PPS, and other variables. Results Totally, 17 RCTs with 3253 patients were identified. Median OS was strongly and moderately associated with median PPS and PFS, respectively ( r  = 0.913; p  
ISSN:0167-6997
1573-0646
DOI:10.1007/s10637-018-0589-6