Serum 25‐hydroxyvitamin D levels in hospitalized adults with community‐acquired pneumonia

Introduction Community‐acquired pneumonia (CAP) is the infectious disease with the highest number of deaths worldwide. Several studies have shown an association between vitamin D deficiency and increases susceptibility to respiratory tract infections. Objective The aim of this study was to evaluate...

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Published in:The clinical respiratory journal 2018-07, Vol.12 (7), p.2220-2227
Main Authors: Brance, María L., Miljevic, Julio N., Tizziani, Raquel, Taberna, María E., Grossi, Georgina P., Toni, Pablo, Valentini, Elina, Trepat, Andrea, Zaccardi, Julia, Moro, Juan, Finuci Curi, Baltasar, Tamagnone, Norberto, Ramirez, Mariano, Severini, Javier, Chiarotti, Pablo, Consiglio, Francisco, Piñeski, Raúl, Ghelfi, Albertina, Kilstein, Jorge, Street, Eduardo, Moretti, Dino, Oliveto, Viviana, Mariño, Marcelo, Manera, Jorge, Brun, Lucas R.
Format: Article
Language:English
Subjects:
25‐hydroxyvitamin D
Adult
Age Factors
Aged
Aged, 80 and over
Argentina
Community-Acquired Infections - blood
community‐acquired pneumonia
Comorbidity
Female
Hospitalization
Humans
Male
Middle Aged
Pneumonia
Pneumonia - blood
severity
Sex Factors
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - diagnosis
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Summary:Introduction Community‐acquired pneumonia (CAP) is the infectious disease with the highest number of deaths worldwide. Several studies have shown an association between vitamin D deficiency and increases susceptibility to respiratory tract infections. Objective The aim of this study was to evaluate the serum 25‐hydroxyvitamin D (25OHD) levels in hospitalized adults in general room with CAP. Materials and methods An observational study was carried out in 207 hospitalized adults of both sex with CAP (>18 years) from Rosario city, Argentina (32° 52′ 18″S) between July 2015 and June 2016. Results In total, 167 patients were included in the data analysis [59% women (57.4 ± 19.6 years), body mass index 27.2 ± 7.8 kg/m2]. In brief, 63% showed unilobar infiltrate and 37% were multilobar. The CURB‐65 index was 66.5% low risk, 16.0% intermediate risk and 17.5% high risk. According to Charlson comorbidity index (CCI) 53.5% had not comorbidity (CCI = 0) and 46.5% showed CCI ≥ 1. The 25OHD level was: 11.92 ± 7.6 ng/mL (51.5%: 30 ng/mL). Higher 25OHD were found in male (female: 10.8 ± 6.7 ng/mL, male: 13.5 ± 8.5 ng/mL, P = .02) and 25OHD correlated with age (r = –.17; P = .02). 25‐Hydroxyvitamin D was also correlated with CURB65 index (r = –.13; P = .049), CCI (r = –.20, P = .007) and with the 10 years of life expectative (%) (r = .19; P = .008). In addition, higher 25OHD were found with lower CCI (CCI 0 = 13.0 ± 8.2 ng/mL, CCI ≥ 1= 10.5 ± 6.7 ng/mL; P = .0093). Conclusions Hospitalized adults with CAP have lower 25OHD levels and would be associated with the severity of CAP.
ISSN:1752-6981
1752-699X
DOI:10.1111/crj.12792