Impact on platelet recovery of recombinant human thrombopoietin in severe aplastic anemia patients with allogeneic hematopoietic stem cell transplantation

To investigate and analyze the impact on PLT recovery of recombinant human thrombopoietin (rhTPO) in severe aplastic anemia (SAA) patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT). A retrospective analysis of Hematology Division of General Hospital of Jinan Military Comman...

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Bibliographic Details
Published in:Zhōnghuá xuèyèxué zázhì 2018-03, Vol.39 (3), p.207
Main Authors: Song, Y, Zhou, F, Song, N X, Liu, X M, Yu, Z, Xie, L N, Song, X C, Li, X
Format: Article
Language:Chinese
Subjects:
Anemia, Aplastic - therapy
Blood Platelets
Hematopoietic Stem Cell Transplantation
Humans
Platelet Count
Recombinant Proteins
Retrospective Studies
Thrombopoietin
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Summary:To investigate and analyze the impact on PLT recovery of recombinant human thrombopoietin (rhTPO) in severe aplastic anemia (SAA) patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT). A retrospective analysis of Hematology Division of General Hospital of Jinan Military Command was conducted in the 85 SAA cases who treated with allo-HSCT from January 2010 to March 2017. According to the administration of medicines for platelets, 85 patients were divided into rhTPO group ( =29), rhIL-11 group ( =27) and blank group ( =29), respectively. The median time of PLT ≥20×10 /L, PLT ≥50×10 /L, and PLT ≥100×10 /L, the numbers of megakaryocytes in marrow smear (25±5) days after transplantation and the quantities of platelet transfusion were analyzed retrospectively. The adverse events of rhTPO and rhIL-11 groups were observed. There were no significant differences in the recovery of granulocytes and PLT ≥20×10 /L among the three groups ( >0.05). The time of PLT ≥50×10 /L in rhTPO group was shorter
ISSN:0253-2727
DOI:10.3760/cma.j.issn.0253-2727.2018.03.007