Application of the 8th edition of the AJCC yTNM staging system shows improved prognostication in a single center cohort of esophageal carcinomas

The 8th edition of the AJCC TNM staging system presents for the first time a specific classification for esophageal carcinomas treated with neoadjuvant therapy (yTNM8). In this single center study, we applied the novel staging system in a “real life” case series and compared the prognostic value of...

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Bibliographic Details
Published in:Surgical oncology 2018-03, Vol.27 (1), p.100-105
Main Authors: Kröll, Dino, Noser, Laura, Erdem, Suna, Storni, Federico, Arnold, Dominik, Dislich, Bastian, Zlobec, Inti, Candinas, Daniel, Seiler, Christian A., Langer, Rupert
Format: Article
Language:English
Subjects:
Abdomen
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adult
Aged
Aged, 80 and over
Bayesian analysis
Biopsy
Cancer
Cancer therapies
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Chemotherapy
Classification
Cohort Studies
Criteria
Data acquisition
Data processing
Dissection
Esophageal cancer
Esophageal carcinoma
Esophageal Neoplasms - pathology
Esophageal Neoplasms - surgery
Esophagectomy
Esophagus
Female
Follow-Up Studies
Gastric cancer
Goodness of fit
Humans
Lymphatic system
Male
Medical prognosis
Metastasis
Middle Aged
Neoadjuvant therapy
Neoplasm Staging - standards
Ostomy
Staging
Surgery
Survival analysis
Survival Rate
Therapy
TNM
Tumors
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Summary:The 8th edition of the AJCC TNM staging system presents for the first time a specific classification for esophageal carcinomas treated with neoadjuvant therapy (yTNM8). In this single center study, we applied the novel staging system in a “real life” case series and compared the prognostic value of yTNM8 with the preceding 7th edition (TNM7). Out of 272 consecutive esophageal carcinomas that were treated during a 15-year period in one surgical center, all 198 cases that had undergone neoadjuvant therapy were reviewed and classified according to TNM7 and yTNM8. 50 ypT0 cases that had no specific staging in TNM7 were included into stages I (ypT0N0M0; n = 42), IIIA (ypT0N1M0; n = 6), IVA (ypT0N3M0; n = 1) and IVB (ypT0N0M1; n = 1) in yTNM8. Both systems showed significant prognostic impact (p 
ISSN:0960-7404
1879-3320
DOI:10.1016/j.suronc.2017.12.005