The influence of antidotal treatment of low-level tabun exposure on cognitive functions in rats using a water maze

In this study, the influence of antidotal treatment of tabun poisoning on cognitive function, in the case of low-level tabun exposure, was studied. The impairment of cognitive function was evaluated by the measurement of spatial learning and memory in rats poisoned with a sublethal dose of tabun and...

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Bibliographic Details
Published in:Neurotoxicity research 2006-01, Vol.9 (1), p.39-45
Main Authors: Kassa, J, Kunesova, G
Format: Article
Language:English
Subjects:
Animals
Antidotes - pharmacology
Atropine - pharmacology
Behavior, Animal
Cognition - drug effects
Drug Interactions
Male
Maze Learning - drug effects
Muscarinic Antagonists - pharmacology
Organophosphates - pharmacology
Oximes - pharmacology
Pyridinium Compounds - pharmacology
Rats
Rats, Wistar
Reaction Time - drug effects
Time Factors
Trimedoxime - pharmacology
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Summary:In this study, the influence of antidotal treatment of tabun poisoning on cognitive function, in the case of low-level tabun exposure, was studied. The impairment of cognitive function was evaluated by the measurement of spatial learning and memory in rats poisoned with a sublethal dose of tabun and treated with atropine alone or in combination with newly developed oximes {K027 [1-(4-hydroxyiminomethyl- pyridinium)-3-(4-carbamoylpyridinium) propane dibromide] and K048 [1-(4-hydroxyimino- methylpyridinium)-3-(4-carbamoylpyridinium) butane dibromide]} or currently available oxime (trimedoxime), using the Morris water maze. While atropine alone caused an impairment of studied cognitive functions, the addition of an oxime to atropine contributes to the improvement of cognitive performance of treated tabun-poisoned rats regardless of the type of oxime. The differences in the ameliorative effects of oximes on atropine-induced mnemonic deficits were not significant. Therefore, each low-level nerve agent exposure should be treated by complex antidotal treatment consisting of anticholinergic drug and oxime.
ISSN:1029-8428
1476-3524
DOI:10.1007/BF03033306